Results 71 to 80 of about 853,002 (309)

Endogenous mammalian lectin localized extracellularly in lung elastic fibers. [PDF]

, 1984
An affinity-purified antibody preparation raised against a beta-galactoside-binding lectin from bovine lung was used to localize a similar lectin in rat lung by immunofluorescence and by electron microscopy after on-grid staining visualized with ...
Barondes, SH, Cerra, RF, Haywood-Reid, PL   +2 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PROTEOMIC COMPARISON OF EXTRACELLULAR MATRIX WITHIN LIVER METASTASES OF COLORECTAL CANCER AND NORMAL LIVER

Фундаментальная и клиническая медицина, 2018
Aim. To investigate the composition of extracellular matrix proteins in colorectal cancer liver metastases and normal liver. Materials and Methods.
ARSENIY E. Yuzhalin, RUTH J. Muschel
doaj  

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]

, 2015
20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
A Osaka, A Rucavado, A Rucavado, AF Pinto, AK Oliveira, Alexandra Rucavado, AM Moura-da-Silva, AM Moura-da-Silva, Ana Moura, BG Fry, C Baldo, Cristina Herrera, DB Gould, Diego Morazán, E Camacho, EN Baramova, EN Baramova, EN Baramova, J Durban, Jay W. Fox, JJ Calvete, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, José María Gutiérrez, Juan J. Calvete, JW Fox, Jéssica Kele A. Macêdo, K Kühn, K Kühn, L Watanabe, Libia Sanz, Mathieu-Benoit Voisin, N Jiménez, NR Casewell, NR Casewell, NR Casewell, PD Yurchenco, PD Yurchenco, R Timpl, SM Serrano, SM Serrano, SM Serrano, Sussan Nourshargh, SV Costes, T Escalante, T Escalante, T Escalante, T Nikai, Teresa Escalante, UK Laemmli, WJ Wang   +52 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. [PDF]

, 2001
The epithelial-mesenchymal interactions required for kidney organogenesis are disrupted in mice lacking the integrin alpha8beta1. None of this integrin's known ligands, however, appears to account for this phenotype. To identify a more relevant ligand, a
Backus, C, Brandenberger, R, Denda, S, Linton, J, Müller, U, Reichardt, LF, Schmidt, A, Wang, D   +7 more
core  

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Construction of Artificial Ovaries with Decellularized Porcine Scaffold and Its Elicited Immune Response after Xenotransplantation in Mice

Journal of Functional Biomaterials, 2022
Substitution by artificial ovary is a promising approach to restore ovarian function, and a decellularized extracellular matrix can be used as a supporting scaffold. However, biomimetic ovary fabrication and immunogenicity requires more investigation. In
Tong Wu, Yue-Yue Gao, Xia-Nan Tang, Jin-Jin Zhang, Shi-Xuan Wang   +4 more
doaj   +1 more source

Adhesion of a chicken myeloblast cell line to fibrinogen and vitronectin through a beta 1-class integrin. [PDF]

, 1992
The adhesive interactions of circulating blood cells are tightly regulated, receptor-mediated events. To establish a model for studies on regulation of cell adhesion, we have examined the adhesive properties of the HD11 chick myeloblast cell line ...
Neugebauer, KM, Reichardt, LF, Venstrom, KA   +2 more
core   +1 more source