Results 61 to 70 of about 3,841,681 (257)

Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis

JACC: Basic to Translational Science, 2023
Summary: Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis.
Nikolaos Anousakis-Vlachochristou, MD, Dimitra Athanasiadou, PhD, Karina M.M. Carneiro, PhD, Konstantinos Toutouzas, MD   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus [PDF]

, 2004
Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients’ sera.
Sallie M. Neill, Hughes, GJ, Ien Chan, Andrew P. South, Black, Martin M., Oyama, N, McGrath, John A., McGrath, J A, Kawakami, Y, Fenella Wojnarowska, John A. McGrath, Mepani, K, Balbir S. Bhogal, South, AP, South, A P, Chan, Ien, Kaneko, F, Kawakami, Yoshio, Chan, I, Kirti Mepani, South, Andrew P., Bhogal, BS, Neill, Sallie M., Oyama, Noritaka, Bhogal, B S, Noritaka Oyama, Bhogal, Balbir S., David D’Cruz, Neill, SM, Mepani, Kirti, McGrath, JA, Fumio Kaneko, Kaneko, Fumio, D'Cruz, David, Hughes, G J, D'Cruz, D, Martin M. Black, Graham J. Hughes, Neill, S M, Hughes, Graham J., Yoshio Kawakami, Wojnarowska, F, Black, MM, Black, M M, Wojnarowska, Fenella   +44 more
core   +1 more source

Inflammation modulates expression of laminin in the central nervous system following ischemic injury

Journal of Neuroinflammation, 2012
Background Ischemic stroke induces neuronal death in the core of the infarct within a few hours and the secondary damage in the surrounding regions over a long period of time.
Ji Kyungmin, Tsirka Stella E
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Extracellular Matrix Proteases - Cytokine Regulation Role in Cancer and Pregnancy

, 2010
The extracellular matrix proteases act in diverse physiological and pathological processes involving tumor growth, angiogenesis, and pregnancy through the cleavage of extracellular matrix (ECM) and non-matrix proteinaceous substrates.
許博欽;張文君;王鵬惠;林世明;黃思誠, SHEU, BOR-CHING;CHANG, WEN-CHUN;WANG, PENG-HUI;LIN, SHIMING;HUANG, SU-CHENG   +1 more
core   +1 more source

Extracellular Matrix Proteins and Tumor Angiogenesis [PDF]

, 2010
Tumor development is a complex process that relies on interaction and communication between a number of cellular compartments. Much of the mass of a solid tumor is comprised of the stroma which is richly invested with extracellular matrix.
N. E. Campbell, Greenaway, J., L. Kellenberger, Moorehead, R. A., Kellenberger, L., Campbell, N. E., R. A. Moorehead, Petrik, J., N. M. Linnerth-Petrik, J. Greenaway, J. Petrik, Linnerth-Petrik, N. M.   +11 more
core   +1 more source

Prediction of Extracellular Matrix Proteins by Fusing Multiple Feature Information, Elastic Net, and Random Forest Algorithm

Mathematics, 2020
Extracellular matrix (ECM) proteins play an important role in a series of biological processes of cells. The study of ECM proteins is helpful to further comprehend their biological functions.
Minghui Wang, Lingling Yue, Xiaowen Cui, Cheng Chen, Hongyan Zhou, Qin Ma, Bin Yu   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source