Results 61 to 70 of about 853,002 (309)

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

Experimental and Molecular Medicine, 2019
Aortic aneurysm: Different locations, different causes A review of aneurysm formation, swelling in blood vessel, in the aorta, examines distinctions between two forms of the condition and the role of proteins in the extracellular matrix which surrounds ...
Sayantan Jana, Mei Hu, Mengcheng Shen, Zamaneh Kassiri   +3 more
doaj   +1 more source

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Bella, Blombäck, Chang, De Almeida, De Rycke, Everse, Fan, Gregersen, Hynes, Ioan-Facsinay, Klareskog, Li, Mahdi, McInnes, Meyer, Mikuls, Mundlos, Panayi, Perry, Ruiz-Esquide, Scher, Scott, Sofat, Symmons, Van Beers, van der Woude, van Heemst, Vincent, Wegner, Wellcome Trust Case Control Consortium, Weyand, Williams   +31 more
core   +3 more sources

Solution Conformation of Extracellular Matrix Proteins [PDF]

Biophysical Journal, 2012
The extracellular matrix (ECM) is composed of large, multi-domain proteins with varying degree of shapes and post-translational modifications. Therefore, it is challenging to study such proteins with a single technique to gain reliable information about their size, shape and conformation. We have employed a multidisciplinary approach using a variety of
Patel, Trushar R., Stetefeld, Joerg
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]

, 2015
The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John, Coito, Ana J, Duarte, Sergio, Fujii, Takehiro   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

International Journal of Nanomedicine, 2012
Fernanda MP Tonelli,1 Anderson K Santos,1 Katia N Gomes,2 Eudes Lorençon,2 Silvia Guatimosim,3 Luiz O Ladeira,2 Rodrigo R Resende11Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Federal University ...
Tonelli FM, Santos AK, Gomes KN, Lorençon E, Guatimosim S, Ladeira LO, Resende RR   +6 more
doaj  

Fibroblasts in the Infarcted, Remodeling, and Failing Heart

JACC: Basic to Translational Science, 2019
Summary: Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction.
Claudio Humeres, PhD, Nikolaos G. Frangogiannis, MD   +1 more
doaj   +1 more source

Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis

JACC: Basic to Translational Science, 2023
Summary: Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis.
Nikolaos Anousakis-Vlachochristou, MD, Dimitra Athanasiadou, PhD, Karina M.M. Carneiro, PhD, Konstantinos Toutouzas, MD   +3 more
doaj   +1 more source