Results 251 to 260 of about 853,002 (309)

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Hsa-MiR-483 -3p Regulates the Extracellular Matrix Proteins via TGFβ2/SMAD4 Signaling in the Glucocorticoid-responsive Human Trabecular Meshwork Cells

Haribalaganesh R, Sharmila R, Krishnadas R, Willoughby CE, Senthilkumari S.   +4 more
europepmc   +1 more source

A Novel P-III Metalloproteinase from <i>Bothrops barnetti</i> Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules. [PDF]

Toxins (Basel)
Schluga PHC, Larangote D, de Melo AM, Lobermayer GK, Torrejón D, de Oliveira LS, Alvarenga VG, Vivas-Ruiz DE, Veiga SS, Sanchez EF, Gremski LH.   +10 more
europepmc   +1 more source

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Fibulins: a versatile family of extracellular matrix proteins

Nature Reviews Molecular Cell Biology, 2003
Fibulins are a newly recognized family of extracellular matrix proteins. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains.
Timpl, R., Sasaki, T., Kostka, G., Chu, M.   +3 more
openaire   +5 more sources

Making recombinant extracellular matrix proteins

Methods, 2008
A variety of approaches to understand extracellular matrix protein structure and function require production of recombinant proteins. Moreover, the expression of heterologous extracellular matrix proteins, in particular collagens, using the recombinant technology is of major interest to the biomedical industry.
Ruggiero, Florence, Koch, M.
openaire   +3 more sources

Extracellular Matrix Proteins Involved in Alzheimer's Disease

Chemistry – A European Journal, 2020
AbstractAlzheimer's disease (AD) is one of the most common neurodegenerative diseases and characterized by cognitive and memory impairments. Emerging evidence suggests that the extracellular matrix (ECM) in the brain plays an important role in the etiology of AD.
Jun Ma, Chao Ma, Jingjing Li, Yao Sun, Fangfu Ye, Kai Liu, Hongjie Zhang   +6 more
openaire   +2 more sources

Extracellular matrix proteins of dentine.

Ciba Foundation symposium, 1997
Bone and dentine extracellular matrix proteins are similar, consisting primarily of type I collagen, acidic proteins and proteoglycans. Although collagen forms the lattice for deposition of calcium and phosphate for formation of carbonate apatite, the non-collagenous proteins are believed to control initiation and growth of the crystals.
W T, Butler, H H, Ritchie, A L, Bronckers   +2 more
openaire   +2 more sources