Results 111 to 120 of about 5,777,110 (367)

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model

Frontiers in Cellular Neuroscience
Astrocytes are crucial for the functioning of the nervous system as they maintain the ion homeostasis via volume regulation. Pathological states, such as amyotrophic lateral sclerosis (ALS), affect astrocytes and might even cause a loss of such functions.
Tereza Filipi, Tereza Filipi, Jana Tureckova, Ondrej Vanatko, Ondrej Vanatko, Martina Chmelova, Monika Kubiskova, Monika Kubiskova, Natalia Sirotova, Natalia Sirotova, Stanislava Matejkova, Lydia Vargova, Miroslava Anderova   +12 more
doaj   +1 more source

Cellular Pushing Forces during Mitosis Drive Mitotic Elongation in Collagen Gels

Advanced Science, 2021
Cell elongation along the division axis, or mitotic elongation, mediates proper segregation of chromosomes and other intracellular materials, and is required for completion of cell division.
Sungmin Nam, Yung‐Hao Lin, Taeyoon Kim, Ovijit Chaudhuri   +3 more
doaj   +1 more source

Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space

Journal of Neuroscience, 2014
Hyaluronan (HA), a large anionic polysaccharide (glycosaminoglycan), is a major constituent of the extracellular matrix of the adult brain. To address its function, we examined the neurophysiology of knock-out mice deficient in hyaluronan synthase (Has ...
Amaia M. Arranz, K. L. Perkins, F. Irie, D. P. Lewis, J. Hrabe, F. Xiao, N. Itano, K. Kimata, S. Hrabetova, Y. Yamaguchi   +9 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments

Cell Reports, 2017
In the CNS, glutamate is both phasically and tonically released into the extracellular space and must be removed by excitatory amino acid transporters (EAATs) to prevent excitotoxic accumulation.
Delia N. Chiu, Craig E. Jahr
doaj   +1 more source

Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions.
Mudasir A Kumar, S. K. Baba, Hana Q. Sadida, Sara Al Marzooqi, J. Jerobin, Faisal H. Altemani, Naseh A Algehainy, Mohammad A. Alanazi, Abdul-Badi Abou-Samra, Rakesh Kumar, AMMIRA-SARAH AL-SHABEEB AKIL, M. Macha, Rashid Mir, Ajaz A. Bhat   +13 more
semanticscholar   +1 more source

Brain extracellular space as a diffusion barrier [PDF]

Computing and Visualization in Science, 2011
The extracellular space (ECS) consists of the narrow channels between brain cells together with their geometrical configuration and contents. Despite being only 20-60 nm in width, the ECS typically occupies 20% of the brain volume. Numerous experiments over the last 50 years have established that molecules moving through the ECS obey the laws of ...
Padideh Kamali-Zare, Lian Tao, Charles Nicholson   +2 more
openaire   +3 more sources

Excitable Media Seminar [PDF]

, 2012
The simulation data presented here, and the conceptual framework developed for their interpretation are, both, in need of substantial refinement and extension.
Werner, prof. Gerhard
core