Results 231 to 240 of about 596,635 (290)

PolyGraph – Flexible, Biocompatible & Electrically Optimized Graphene‐Polymer Composites for Next‐Generation Neural Interfaces

Advanced Healthcare Materials, EarlyView.
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti, Eoin Caffrey, Jose M. Munuera, Tian Carey, Adrian Dervan, Alejandro López Valdés, Omar Mamad, Maeve A. Caldwell, Fergal J. O'Brien, Jonathan N. Coleman   +12 more
wiley   +1 more source

Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony‐Forming Cells

Advanced Healthcare Materials, EarlyView.
A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level, Marc‐Antoine Campeau, Mohamed A. Elkhodiry, Gaétan Laroche, Jean‐François Tanguay, Corinne A. Hoesli   +5 more
wiley   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells.

Am J Physiol Cell Physiol
Gardner JJ, Cushen SC, Oliveira da Silva RN, Bradshaw JL, Hula N, Gorham IK, Tucker SM, Zhou Z, Cunningham RL, Phillips NR, Goulopoulou S.   +10 more
europepmc   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture

Advanced Healthcare Materials, EarlyView.
Inspired by the water‐rich and interconnected biopolymer networks of native load‐bearing tissues, we disclose a connectable design for a hybrid filamentous supramolecular and covalent double network hydrogel generated through in situ photopolymerization.
Ciqing Tong, Ying Chen, Merel L. Janssen, Isabel Sariol, Joeri A. J. Wondergem, Marijn van den Brink, Mertcan Özel, Rob G. H. H. Nelissen, Ingrid Meulenbelt, Doris Heinrich, Yolande F. M. Ramos, Roxanne E. Kieltyka   +11 more
wiley   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Wound Geometry Determines Whether Aligned‐Fiber Scaffolds Accelerate or Impede Diabetic Wound Healing: A Biased Random Walk Analysis

Advanced Healthcare Materials, EarlyView.
Wound closure is governed by geometry‐orientation coupling: aligned fibers speed migration along their axis but hinder perpendicular advance. In vivo diabetic wound experiments with composition‐matched fibrin, combined with an anisotropic diffusion (biased random‐walk) model, quantify this trade‐off and generate a healing landscape.
Yin‐Yuan Huang, Xiangjun Peng, Yuxuan Huang, Kunkoo Kim, Chengli Li, Peilun Hu, Sean J. Wang, Rohan Avula, Chun‐Yi Yang, Pengchao Ma, Shuhui Yang, Shumeng Jiang, Guy M. Genin, Xiumei Wang   +13 more
wiley   +1 more source

Temporally Delayed Deployment of Photo‐Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces

Advanced Healthcare Materials, EarlyView.
Deployable medical devices typically need external stimuli to trigger deployment. However, external stimuli are difficult to supply within tissues. Here, we describe a strategy to deploy small‐scale structures into soft tissues after insertion without the need for any stimulus. We demonstrate deployment within a tissue phantom.
Yeh‐Chia Tseng, Eleanor Nguyen Jeakle, Mahjabeen Javed, Rajasree Gopala Krishnan, Thomas J. Smith, Yoo Jin Lee, Sahana Dhananjayan, Sasha M. George, Manivannan Sivaperuman Kalairaj, Ali Hasan Zuaiter, Majed O. Althumayri, Hatice Ceylan Koydemir, Joseph J. Pancrazio, Taylor H. Ware   +13 more
wiley   +1 more source