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Editorial: Brain Extracellular Space: Geometry, Matrix and Physiological Importance
Padideh Kamali-Zare, Charles Nicholson
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Molecular mechanisms of K+ clearance and extracellular space shrinkage—Glia cells as the stars
Glia, 2020Neuronal signaling in the central nervous system (CNS) associates with release of K+ into the extracellular space resulting in transient increases in [K+]o. This elevated K+ is swiftly removed, in part, via uptake by neighboring glia cells.
N. MacAulay
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Alarmins of the extracellular space
Seminars in Immunology, 2018The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes ranging from propagation of disease ...
George S. Hussey+2 more
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The extracellular space of the lens
Experimental Eye Research, 1965The extracellular space of rat, rabbit and calf lenses has been estimated in vitro using radioactive non-metabolized carbohydrates and 24Na as test substances. The size of the extracellular space ranges from 4 to 13% of the lens water, depending on the test substance used.
Jin H. Kinoshita, Richard A. Thoft
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Selective Radioprotection in Extracellular Space
Radiology, 1974Most radioprotective agents are not discriminatory as they can protect both tumor and healthy tissue. The effects of radioprotective agents on radiation-induced free radicals in the extracellular ground substance were investigated by ESR spectroscopy.
Ira Pullman+2 more
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Journal of Neurotrauma, 2018
Traumatic brain injury (TBI) has high morbidity and mortality rates. The mechanisms underlying TBI are unclear and may include the change in biological material in exosomes. Circular ribonucleic acids (circRNAs) are enriched and stable in exosomes, which
Ruibo Zhao+8 more
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Traumatic brain injury (TBI) has high morbidity and mortality rates. The mechanisms underlying TBI are unclear and may include the change in biological material in exosomes. Circular ribonucleic acids (circRNAs) are enriched and stable in exosomes, which
Ruibo Zhao+8 more
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Extracellular Space Measurements [PDF]
The volume of the extracellular space in smooth muscle preparations is frequently required in the interpretation of studies of smooth muscle function. Recent examples include studies of: the mechanism of control of cellular volume (Brading, 1970); the fluxes of cations (Casteels, 1970; Goodford, 1970; Jones, 1970); the effects of Na+ pumping on ...
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The Extracellular Space of the Brain
1965Publisher Summary This chapter discusses the extracellular space of the brain. Some 10–15 % of the volume of the brain behaves as though it were extracellular, in the sense that under appropriate conditions an extracellular “tag,” such as sucrose, will come into equilibrium with it. The appropriate condition is that the sucrose should be presented by
M. Bradbury, H. Davson
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Glucose Concentration in Subcutaneous Extracellular Space
Diabetes Care, 1993OBJECTIVE To compare the subcutaneous glucose sensor measurements with two reference methods. Previous studies provide conflicting findings about the real glucose concentrations in subcutaneous tissue. Some suggest substantially lower concentration, whereas others measure proportionally higher glucose concentrations
Adelbert Jm Schoonen+2 more
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The extracellular space and matrix of gliomas
Acta Neuropathologica, 2005Changes in the properties of extracellular space (ECS)--its volume, shape, and composition--play an important role in influencing the biological behavior of brain tumors. Experimental methods allowing assessment of the volume and geometry of ECS by means of analyzing the diffusion of molecules within ECS have revealed a dramatic increase in the ECS ...
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