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Tracking extracellular space in the brain
Science, 2016Neuroscience Extracellular space takes up a large percentage of the brain. Its size changes with the sleep-wake cycle but also during brain development and normal aging, as well as under pathological conditions such as neurodegeneration. Godin et al. injected near-infrared luminescent carbon nanotubes into rat brains and tracked their diffusion in the ...
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Plasticity of Extracellular Space
2002The extracellular space (ECS) of the nervous tissue is a microenvironment for nerve cells, and an important communication channel (1–4). It includes ions, transmitters, metabolites, peptides, neurohormones, other neuroactive substances, and molecules of the extracellular matrix (ECM), and directly or indirectly affects neuronal and glial cell functions.
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Wringing out the Extracellular Space
New England Journal of Medicine, 1974Several years ago I visited a new hemodialysis unit and was proudly shown an oliguric patient whose plasma electrolytes had reverted to normal after repeated dialyses.
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The determination of extracellular space using hemoglobin [PDF]
Experientia, 1978 The ECS of guinea-pig atria and frog sartorii can be determined using hemoglobin. For guinea-pig atria an ECS of (32.2 +/- 2.6)% wet wt for frog sartorii an ECS of (12.4 +/- 1.0)% wet wt can be measured.
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Extracellular space determination in gallbladder mucosa
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975Abstract Sucrose seems to be the best marker of the extracellular space in gallbladder mucosa. Inulin space is always smaller than sucrose space and the difference seems to be due to a sweeping-away effect in the intercellular channels as metabolic inhibitors and ouabain reduce it. Mannitol space continuously increases and this substance is likely to
S Hénin, Dario Cremaschi
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The extracellular space of rat intestine ?in vivo?
Pfl�gers Archiv European Journal of Physiology, 1972The extracellular space (ECS) of rat jejunum, ileum and colon were determined in “in vivo” condition both by means of a continuous perfusion technique and after ligature of the renal pedicles. As a marker, intravenously injected14C-polyethylenglycol (14C-PEG) was used.
Alide Faelli, V. Capraro, G. Esposito
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2001 interactions? An extracellular space odyssey
Current Opinion in Neurobiology, 1991Abstract Recent investigation has revealed an incredible degree of complexity in the types and functions of extracellular matrix molecules and their cellular receptors in the nervous system.
Karla M. Neugebauer, Kevin J. Tomaselli
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Diffusion Parameters of the Extracellular Space
Israel Journal of Chemistry, 2003AbstractExtrasynaptic communication between neurons or neurons and glia is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). Diffusion in the central nervous system (CNS) is inhomogeneous and often anisotropic. Changes in ECS volume and geometry accompany physiological neuronal activity, development, lactation ...
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Regional Variation of Extracellular Space in the Hippocampus
Science, 1990The factors responsible for the unusual susceptibility of the hippocampus to seizures and ischemic cell damage are not well understood. The CA1 pyramidal subfield of the hippocampus is particularly vulnerable to seizure activity and damage after ischemia.
Stephen F. Traynelis +2 more
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