Results 91 to 100 of about 13,987 (204)

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Nature Genetics, 2023
AbstractCircular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and reconstruction of ecDNA across a retrospective cohort of 481 medulloblastoma tumors from 465 patients, we identify circular ...
Owen S. Chapman, Jens Luebeck, Sunita Sridhar, Ivy Tsz-Lo Wong, Deobrat Dixit, Shanqing Wang, Gino Prasad, Utkrisht Rajkumar, Meghana S. Pagadala, Jon D. Larson, Britney Jiayu He, King L. Hung, Joshua T. Lange, Siavash R. Dehkordi, Sahaana Chandran, Miriam Adam, Ling Morgan, Sameena Wani, Ashutosh Tiwari, Caitlin Guccione, Yingxi Lin, Aditi Dutta, Yan Yuen Lo, Edwin Juarez, James T. Robinson, Andrey Korshunov, John-Edward A. Michaels, Yoon-Jae Cho, Denise M. Malicki, Nicole G. Coufal, Michael L. Levy, Charlotte Hobbs, Richard H. Scheuermann, John R. Crawford, Scott L. Pomeroy, Jeremy N. Rich, Xinlian Zhang, Howard Y. Chang, Jesse R. Dixon, Anindya Bagchi, Aniruddha J. Deshpande, Hannah Carter, Ernest Fraenkel, Paul S. Mischel, Robert J. Wechsler-Reya, Vineet Bafna, Jill P. Mesirov, Lukas Chavez   +47 more
openaire   +4 more sources

Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system.

PLoS ONE, 2009
Extrachromosomal circular DNA (eccDNA) is a pool of circular double stranded DNA molecules found in all eukaryotic cells and composed of repeated chromosomal sequences. It was proposed to be involved in genomic instability, aging and alternative telomere
Zoya Cohen, Sara Lavi
doaj   +1 more source

Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]

, 1997
The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core  

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, Volume 13, Issue 2, 9 January 2026.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

Extrachromosomal circular DNA: A neglected nucleic acid molecule in plants

Current Opinion in Plant Biology, 2022
Throughout the years, most plant genomic studies were focused on nuclear chromosomes. Extrachromosomal circular DNA (eccDNA) has largely been neglected for decades since its discovery in 1965. While initial research showed that eccDNAs can originate from highly repetitive sequences, recent findings show that many regions of the genome can contribute to
Peng, Haoran, Mirouze, Marie, Bucher, Etienne   +2 more
openaire   +2 more sources

The genetic architecture and spatiotemporal dynamics of adaptation across human‐modified landscapes

New Phytologist, Volume 249, Issue 2, Page 744-750, January 2026.
Summary Understanding the rate and nature of adaptation is crucial for managing biodiversity across our changing landscapes. This perspective synthesizes insights from resistance evolution – a case of rapid, repeated adaptation to extreme human‐mediated selection – to reveal how adaptive genetic architectures determine and feedback with evolutionary ...
Julia M. Kreiner
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, Volume 599, Issue 24, Page 3669-3684, December 2025.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, Volume 12, Issue 45, December 4, 2025.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Investigating retrotransposon‐derived DNA and activation of the innate immune response in tauopathy

Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.
Abstract Background Extrachromosomal circular DNA (eccDNA) was extracted from post‐mortem human brain with tauopathy and sequenced. Cytosolic DNA binding proteins and their RNA transcripts were quantified in induced pluripotent stem cells (iPSCs) with tauopathy. Method DNA was extracted from frontal cortex of Alzheimer's disease Braak III and Braak VI,
Morgan Elizabeth Lambert, Paulino Ramirez, Wenyan Sun, Bess Frost   +3 more
wiley   +1 more source

OMIC-01. THE LANDSCAPE OF EXTRACHROMOSOMAL CIRCULAR DNA IN MEDULLOBLASTOMA SUBGROUPS [PDF]

, 2021
Owen Chapman, Jens Luebeck, Shanqing Wang, Alexandra Garancher, Jon D. Larson, Joshua T. Lange, Ivy Tsz Lo Wong, John R. Crawford, Scott L. Pomeroy, Paul S. Mischel, Ernest Fraenkel, Robert J. Wechsler‐Reya, Vineet Bafna, Jill P. Mesirov, Lukas Chávez   +14 more
openalex   +1 more source