Results 91 to 100 of about 40,665 (195)

Extrachromosomal circular DNA: A neglected nucleic acid molecule in plants

Current Opinion in Plant Biology, 2022
Throughout the years, most plant genomic studies were focused on nuclear chromosomes. Extrachromosomal circular DNA (eccDNA) has largely been neglected for decades since its discovery in 1965. While initial research showed that eccDNAs can originate from highly repetitive sequences, recent findings show that many regions of the genome can contribute to
Peng, Haoran, Mirouze, Marie, Bucher, Etienne   +2 more
openaire   +2 more sources

Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression

Cellular and Molecular Life Sciences, 2023
Extrachromosomal circular DNAs (eccDNAs) carrying random genomic segments are broadly found across different cancer types, but their molecular functions and impact in gastric cancer (GC) are rarely known.
Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yu-long He, Xiansheng Xiang   +10 more
semanticscholar   +1 more source

Complete genome sequence of Thermaerobacter marianensis type strain (7p75a). [PDF]

, 2010
Thermaerobacter marianensis Takai et al. 1999 is the type species of the genus Thermaerobacter, which belongs to the Clostridiales family Incertae Sedis XVII. The species is of special interest because T.
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Copeland, Alex, Del Rio, Tijana Glavina, Detter, John C, Eisen, Jonathan A, Goodwin, Lynne, Gu, Wei, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Pagani, Ioanna, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Pukall, Rüdiger, Rohde, Manfred, Schneider, Susanne, Tapia, Roxane, Tice, Hope, Woyke, Tanja, Zhang, Xiaojing   +35 more
core   +1 more source

Mobile circular DNAs regulating memory and communication in CNS neurons

Frontiers in Molecular Neuroscience, 2023
Stimuli that stimulate neurons elicit transcription of immediate-early genes, a process which requires local sites of chromosomal DNA to form double-strand breaks (DSBs) generated by topoisomerase IIb within a few minutes, followed by repair within a few
Neil R. Smalheiser
doaj   +1 more source

Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Although the eukaryotic genome is mainly comprised of linear chromosomal DNA, genes can also be found outside of chromosomes. The unconventional presence of extrachromosomal genes is usually found to be circular, and these structures are named extrachromosomal circular DNA (eccDNA), which are often observed in cancer cells.
Tian-Jiao Li, Long-Yun Ye, Xianjun Yu, Liang Liu, Zhenyu Liao, Wang Jiang   +5 more
openaire   +3 more sources

Complete genome sequence of Spirosoma linguale type strain (1). [PDF]

, 2010
Spirosoma linguale Migula 1894 is the type species of the genus. S. linguale is a free-living and non-pathogenic organism, known for its peculiar ringlike and horseshoe-shaped cell morphology. Here we describe the features of this organism, together with
Brettin, Thomas, Bristow, Jim, Bruce, David, Chain, Patrick, Chang, Yun-Juan, Chen, Amy, Chen, Feng, Cheng, Jan-Fang, Copeland, Alex, Detter, John C, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Lail, Kathleen, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Nolan, Matt, Ovchinnikova, Galina, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Saunders, Elizabeth, Schütze, Andrea, Sikorski, Johannes, Tice, Hope, Tindall, Brian J   +36 more
core   +1 more source

eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers

Oncogene, 2022
Extrachromosomal circular DNA (eccDNA) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising star because of its ubiquitous existence in cancers and its crucial role in oncogene ...
Li Peng, Nan Zhou, Chaoyang Zhang, Guancheng Li, Xiao-Qing Yuan   +4 more
semanticscholar   +1 more source

Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus

Cellular & Molecular Biology Letters
Background Extrachromosomal circular DNAs (eccDNAs) exist in human blood and somatic cells, and are essential for oncogene plasticity and drug resistance. However, the presence and impact of eccDNAs in type 2 diabetes mellitus (T2DM) remains inadequately
Xiang Kong, Shu-jun Wan, Tian-Bing Chen, Lan Jiang, Yu-jie Xing, Ya-Ping Bai, Qiang Hua, Xin-ming Yao, Yong-Li Zhao, Hong-Mei Zhang, De-guo Wang, Qing Su, Kun Lv   +12 more
semanticscholar   +1 more source

eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data

Briefings Bioinform.
Extrachromosomal circular DNA (eccDNA) is currently attracting considerable attention from researchers due to its significant impact on tumor biogenesis. High-throughput sequencing (HTS) methods for eccDNA identification are continually evolving. However,
Minghao Fang, Jingwen Fang, Songwen Luo, Ke Liu, Qiaoni Yu, Jiaxuan Yang, Youyang Zhou, Zongkai Li, Ruoming Sun, C. Guo, Kun Qu   +10 more
semanticscholar   +1 more source

Skeletal Muscles of Sedentary and Physically Active Aged People Have Distinctive Genic Extrachromosomal Circular DNA Profiles

International Journal of Molecular Sciences, 2023
To bring new extrachromosomal circular DNA (eccDNA) enrichment technologies closer to the clinic, specifically for screening, early diagnosis, and monitoring of diseases or lifestyle conditions, it is paramount to identify the differential pattern of the
Daniela Gerovska, M. Araúzo-Bravo
semanticscholar   +1 more source