Results 101 to 110 of about 13,987 (204)

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, Volume 82, Issue 12, Page 837-849, December 2025.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors

Stem Cell Research & Therapy, 2023
Background The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have shown that extrachromosomal circular DNAs (eccDNAs) are associated with tumor progression and cell aging, but the roles of ...
Sen Ren, Du Wu, Xiaoyong Shen, Qian Wu, Chengcheng Li, Hewei Xiong, Zhongwei Xiong, Rui Gong, Zheng Liu, Wei Wang, Jincao Chen   +10 more
doaj   +1 more source

Integration of the blaNDM-1 carbapenemase gene into Proteus genomic island 1 (PGI1-PmPEL) in a Proteus mirabilis clinical isolate [PDF]

, 2015
Objectives To decipher the mechanisms and their associated genetic determinants responsible for β-lactam resistance in a Proteus mirabilis clinical isolate.
Dortet, Laurent, Girlich, Delphine, Nordmann, Patrice, Poirel, Laurent   +3 more
core   +2 more sources

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

Computational systems biology approaches to cellular aging—Integrating network maps and dynamical models

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley   +1 more source

Strategies and approaches in plasmidome studies—uncovering plasmid diversity disregarding of linear elements?

, 2015
The term plasmid was originally coined for circular, extrachromosomal genetic elements. Today, plasmids are widely recognized not only as important factors facilitating genome restructuring but also as vehicles for the dissemination of beneficial ...
Dib, J.R. (Julian), Farias, M.E. (Maria), Meinhardt, F. (Friedhelm), Wagenknecht, M. (Martin)   +3 more
core   +1 more source

A molecular cytogenetic perspective on chromosome biology and crop improvement

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Bikram S. Gill
wiley   +1 more source

Bioleaching Microbial Community Metabolism and Composition Driven by Copper Sulphide Mineral Type

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Bioleaching is a microbially mediated green technology for the recovery of metals from ore. Here, microbial consortia from a copper bioleaching column in Cyprus were cultivated on chalcopyrite (CuFeS2) and then sub‐cultured on chalcocite (Cu2S) and chalcopyrite to investigate how mineral type and surface chemistry influence microbial community ...
Katherine R. Lane, Sarah E. Jones, Thomas H. Osborne, David Geller‐McGrath, Bennet C. Nwaobi, LinXing Chen, Brian C. Thomas, Karen A. Hudson‐Edwards, Jillian F. Banfield, Joanne M. Santini   +9 more
wiley   +1 more source

The potential clinical implications of extrachromosomal circular DNA as a biomarker

Genes and Diseases
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from and are independent of conventional chromosomes. The high specificity and stability of the circular structure of eccDNA provide new clues for its research as ...
Xuanmei Luo, Jian Cui, Hexin Li, Gang Zhao, Lihui Zou   +4 more
doaj   +1 more source

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source