Results 111 to 120 of about 13,987 (204)

A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans

Aging Cell, Volume 24, Issue 12, December 2025.
A forward genetic screen in C. elegans identified a nuclear hormone receptor, nhr‐76, as a gene that programs age‐dependent behavioral decline. In post‐reproductive adults, NHR‐76 downregulates odr‐10 that encodes an odorant receptor, leading to impaired chemotaxis.
Rikuou Yokosawa, Kentaro Noma
wiley   +1 more source

Fundamentals of extrachromosomal circular DNA in human cells - Genetic activities as regards cancer promotion alongside chromosomal DNA [PDF]

, 2020
Reinhard H. Dennin
openalex   +3 more sources

Characterization and identification of extrachromosomal circular DNA in cholangiocarcinoma

PLOS One
Extrachromosomal circular DNAs (eccDNAs) have gained attention as key players in cancer heterogeneity, potentially associated with elevated oncogene copy numbers in many cancers. While the presence of eccDNA in both normal and cancer cells is confirmed, its influence on gene-level alterations in cancer cells remains largely unexplored.
Zar Zar Win, Hasaya Dokduang, Siriyakorn Kulwong, Watcharin Loilome, Nisana Namwat, Jutarop Phetcharaburanin, Thidathip Wongsurawat, Piroon Jenjaroenpun, Poramate Klanrit, Arporn Wangwiwatsin   +9 more
openaire   +2 more sources

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data [PDF]

, 2023
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
openalex   +1 more source

Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9 [PDF]

, 2023
Tao Guo, Guoqiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu, Xiaoying Yang, Sicheng Liu, Yi-Li Feng, Pengyuan Liu, Hui Lin, Anyong Xie   +10 more
openalex   +1 more source

Human Smc5/6 recognises transcription-generated positive DNA supercoils

Nature Communications
Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which is lost upon
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin   +5 more
doaj   +1 more source

A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome

Cancer Discovery
Abstract Focal amplifications of oncogenes are important cancer drivers. They can occur on chromosomes or in the context of circular extrachromosomal DNA (ecDNA). Many key features of ecDNAs were described in the 1960s to 1980s, including their “unstable” nature and their ability to confer ...
Natasha E. Weiser, Thomas B.K. Watkins, Howard Y. Chang, Paul S. Mischel   +3 more
openaire   +2 more sources

Extrachromosomal circular DNAs in endosymbiont vesicles fromAlnus glutinosaroot nodules [PDF]

, 1982
Svetlana V. Dobritsa
openalex   +1 more source

Additional file 7 of The extrachromosomal circular DNAs of the rice blast pathogen Magnaporthe oryzae contain a wide variety of LTR retrotransposons, genes, and effectors

, 2022
Pierre M. Joubert, Ksenia V. Krasileva
openalex   +1 more source

The characteristics of extrachromosomal circular DNA in patients with end-stage renal disease [PDF]

, 2023
Yue Peng, Yixi Li, Wei Zhang, Yu Shangguan, Ting Xie, Wang Kang, Jing Qiu, Wenjun Pu, Biying Hu, Xinzhou Zhang, Lianghong Yin, Donge Tang, Yong Dai   +12 more
openalex   +1 more source