Results 111 to 120 of about 40,665 (195)
Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system.
PLoS ONE, 2009 Extrachromosomal circular DNA (eccDNA) is a pool of circular double stranded DNA molecules found in all eukaryotic cells and composed of repeated chromosomal sequences. It was proposed to be involved in genomic instability, aging and alternative telomere
Zoya Cohen, Sara Lavi
doaj +1 more source
BMC Medical Genomics, 2023 Objective Ovarian cancer (OV) has a high mortality rate all over the world, and extrachromosomal circular DNA (eccDNA) plays a key role in carcinogenesis.
Ying Zhang +12 more
semanticscholar +1 more source
Pest Management Science, EarlyView.In this study, multiple herbicide resistant mechanisms have been confirmed in two Amaranthus palmeri populations from Spain that survived glyphosate‐ and ALS‐inhibitor herbicides. Our data suggest that the eccDNA and the mutations identified in the ALS gene are the result of an evolutionary event that occurred outside Spain.
Alfredo Manicardi +5 more
wiley +1 more source
Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]
, 1997 The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source
Quantitative Biology, Volume 13, Issue 4, December 2025.Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley +1 more source
Extrachromosomal circular DNA-related SPOCK1 contributes to development and enzalutamide resistance of prostate cancer by regulating epithelial mesenchymal transition. [PDF]
HeliyonYao Y +9 more
europepmc +2 more sources
Public Health Challenges, Volume 4, Issue 3, September 2025.Whole genome insights into diarrhoeagenic Escherichia coli (DEC) strains from Southern Africa → Study focus: Comparative genomics of DEC strains isolated from food, clinical and environmental sources in Southern Africa. Key Findings: 1. High genetic diversity → Region‐specific distribution system observed from association trends between strains from ...
Josphat Gichure, Tina Hald, Elna Buys
wiley +1 more source
Microbiome Single Cell Atlases Generated with a Commercial Instrument
Advanced Science, Volume 12, Issue 27, July 17, 2025.Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li +8 more
wiley +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Advanced Science, Volume 12, Issue 25, July 3, 2025.Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi +12 more
wiley +1 more source