Results 11 to 20 of about 40,665 (195)

Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer [PDF]

Molecular Medicine
Background Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. Methods We conducted a
Quanpeng Qiu, Yi Ding, Xiaolong Guo, Jing Han, Jiaqi Zhang, Yaping Liu, Junjun She, Yinnan Chen   +7 more
doaj   +6 more sources

Identification and Characterization of Extrachromosomal Circular DNA in Slimming Grass Carp [PDF]

Biomolecules
Slimming grass carp is a commercial variety with good body form and meat quality, which is cultured by starving common grass carp in a clean flowing water environment.
Haobin He, Zihan Gao, Zehua Hu, Guanyu Liang, Yanhua Huang, Meng Zhou, Rishen Liang, Kai Zhang   +7 more
doaj   +5 more sources

Distribution and characterization of extrachromosomal circular DNA in colorectal cancer [PDF]

Molecular Biomedicine, 2022
Extrachromosomal circular DNA (eccDNA) has been shown to play an important role in the amplification of tumor genes and the maintenance of intra-tumor genetic heterogeneity, although its complex functional mechanism still remains to be elucidated. As the
Zhehang Chen, Yadong Qi, Jiamin He, Chaochao Xu, Qiwei Ge, Wei Zhuo, Jianmin Si, Shujie Chen   +7 more
doaj   +4 more sources

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications. [PDF]

Cell Prolif
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Li J, Luo P, Li Z, Wang Q, Huang X, Huang X, Wang K, Wang R, Chen R.   +8 more
europepmc   +4 more sources

Extrachromosomal circular DNA (eccDNA): an emerging star in cancer

Biomarker Research, 2022
Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li, Ying Wang, Jing Li, Xikun Zhou   +3 more
doaj   +4 more sources

Variation of extrachromosomal circular DNA in cancer cell lines [PDF]

Computational and Structural Biotechnology Journal, 2023
The presence of oncogene carrying eccDNAs is strongly associated with carcinogenesis and poor patient survival. Tumour biopsies and in vitro cancer cell lines are frequently utilized as models to investigate the role of eccDNA in cancer. However, eccDNAs
Carl Rung dos Santos, Lasse Bøllehuus Hansen, Monica Rojas-Triana, Astrid Zedlitz Johansen, Mirna Perez-Moreno, Birgitte Regenberg   +5 more
doaj   +6 more sources

A Quick Method to Synthesize Extrachromosomal Circular DNA In Vitro [PDF]

Molecules, 2023
Extrachromosomal circular DNA (eccDNA) is a special class of circular DNA in eukaryotes. Recent studies have suggested that eccDNA is the product of genomic instability and has important biological functions to regulate many downstream biological ...
Shanru Zuo, Xueguang Li, Yide Yang, Junhua Zhou, Quanyuan He   +4 more
doaj   +4 more sources

Extrachromosomal Circular DNA: An Emerging Potential Biomarker for Inflammatory Bowel Diseases? [PDF]

Genes (Basel)
Inflammatory bowel disease (IBD) comprising ulcerative colitis and Crohn’s disease is a chronic immune-mediated disease which affects the gastrointestinal tract with a relapsing and remitting course, causing lifelong morbidity.
Petito V, Di Vincenzo F, Putignani L, Abreu MT, Regenberg B, Gasbarrini A, Scaldaferri F.   +6 more
europepmc   +4 more sources

MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis. [PDF]

J Exp Clin Cancer Res
Background Proteasome inhibitors (PIs) are one of the most important classes of drugs for the treatment of multiple myeloma (MM). However, almost all patients with MM develop PI resistance, resulting in therapeutic failure.
Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H.   +8 more
europepmc   +4 more sources

Extrachromosomal circular DNA-mediated spread of herbicide resistance in interspecific hybrids of pigweed. [PDF]

Plant Physiol, 2023
Extrachromosomal circular DNA mediates the spread and rapid evolution of herbicide resistance in interspecific hybrids of pigweed.
Koo DH, Sathishraj R, Nakka S, Ju Y, Nandula VK, Jugulam M, Friebe B, Gill BS.   +7 more
europepmc   +4 more sources