Results 21 to 30 of about 13,987 (204)

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Signal Transduction and Targeted Therapy, 2022
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Ludi Yang, Ruobing Jia, Tongxin Ge, Shengfang Ge, Ai Zhuang, Peiwei Chai, Xianqun Fan   +6 more
doaj   +3 more sources

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter [PDF]

Neural Regeneration Research
Marcos J. Araúzo-Bravo, Daniela Gerovska, Matthias Schwab, Alexandra Kretz   +3 more
doaj   +4 more sources

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, 2022
Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo   +15 more
doaj   +4 more sources

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells [PDF]

Journal of Visualized Experiments, 2016
Extrachromosomal circular DNAs (eccDNAs) are common genetic elements in Saccharomyces cerevisiae and are reported in other eukaryotes as well. EccDNAs contribute to genetic variation among somatic cells in multicellular organisms and to evolution of ...
Bojsen, Rasmus Kenneth, Botstein, David, Møller, Henrik D., Parsons, Lance, Regenberg, Birgitte, Tachibana, Chris   +5 more
core   +7 more sources

Variation of extrachromosomal circular DNA in cancer cell lines [PDF]

Computational and Structural Biotechnology Journal, 2023
The presence of oncogene carrying eccDNAs is strongly associated with carcinogenesis and poor patient survival. Tumour biopsies and in vitro cancer cell lines are frequently utilized as models to investigate the role of eccDNA in cancer. However, eccDNAs
Carl Rung dos Santos, Lasse Bøllehuus Hansen, Monica Rojas-Triana, Astrid Zedlitz Johansen, Mirna Perez-Moreno, Birgitte Regenberg   +5 more
doaj   +4 more sources

Characterization of Plasma Extrachromosomal Circular DNA in Gouty Arthritis

Frontiers in Genetics, 2022
Objective: Extrachromosomal circular DNA elements (eccDNAs) are known for their broad existence in cells and plasma, which may potentially play important roles in many biological processes. Our aim was to identify potentially functional or marked eccDNAs
Jingyuan Pang, Xiaoguang Pan, Ling Lin, Lei Li, Lei Li, Shuai Yuan, Peng Han, Xiaopeng Ji, Hailong Li, Hailong Li, Can Wang, Zhaobin Chu, Zhaobin Chu, Haoru Wu, Guangyi Fan, Guangyi Fan, Xiao Du, Xiao Du, Aichang Ji, Aichang Ji   +19 more
doaj   +3 more sources

Extrachromosomal circular DNA (eccDNA): an emerging star in cancer

Biomarker Research, 2022
Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li, Ying Wang, Jing Li, Xikun Zhou   +3 more
doaj   +3 more sources

Decoding the genomic enigma: Approaches to studying extrachromosomal circular DNA [PDF]

Heliyon
Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in eukaryotes, eccDNA plays a critical role in the orchestration of cellular processes
Xiao-Qing Yuan, Nan Zhou, Shi-Jian Song, Yi-Xia Xie, Shui-Qin Chen, Teng-Fei Yang, Xian Peng, Chao-Yang Zhang, Ying-Hua Zhu, Li Peng   +9 more
doaj   +2 more sources

A Quick Method to Synthesize Extrachromosomal Circular DNA In Vitro

Molecules, 2023
Extrachromosomal circular DNA (eccDNA) is a special class of circular DNA in eukaryotes. Recent studies have suggested that eccDNA is the product of genomic instability and has important biological functions to regulate many downstream biological ...
Shanru Zuo, Xueguang Li, Yide Yang, Junhua Zhou, Quanyuan He   +4 more
doaj   +3 more sources

Comparative analysis of methodologies for detecting extrachromosomal circular DNA [PDF]

Nature Communications, 2023
AbstractExtrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identification, their detection efficiencies have not been systematically assessed.
Xuyuan Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu, Chen Jiang, Jingwen Fang, Shouzhen Li, Yanbing Hou, Chuang Guo, Kun Qu   +10 more
openalex   +4 more sources