Results 21 to 30 of about 40,665 (195)

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter [PDF]

Neural Regeneration Research
Marcos J. Araúzo-Bravo, Daniela Gerovska, Matthias Schwab, Alexandra Kretz   +3 more
doaj   +5 more sources

Comparative analysis of methodologies for detecting extrachromosomal circular DNA [PDF]

Nature Communications
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identification, their ...
Xuyuan Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu, Chen Jiang, Jingwen Fang, Shouzhen Li, Yanbing Hou, Chuang Guo, Kun Qu   +10 more
doaj   +3 more sources

Extrachromosomal circular DNA and their roles in cancer progression [PDF]

Genes and Diseases
Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma.
Siqi Zheng, Yunong Li, Lin Wang, Qian Wei, Minjie Wei, Tao Yu, Lin Zhao   +6 more
doaj   +4 more sources

Gene Amplification and the Extrachromosomal Circular DNA [PDF]

Genes, 2021
Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred to as cytogenetically visible double minutes (DMs), or submicroscopic episome, or to the chromosomal homogeneously staining region (HSR).
Noriaki Shimizu
openalex   +5 more sources

Decoding the genomic enigma: Approaches to studying extrachromosomal circular DNA [PDF]

Heliyon
Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in eukaryotes, eccDNA plays a critical role in the orchestration of cellular processes
Xiao-Qing Yuan, Nan Zhou, Shi-Jian Song, Yi-Xia Xie, Shui-Qin Chen, Teng-Fei Yang, Xian Peng, Chao-Yang Zhang, Ying-Hua Zhu, Li Peng   +9 more
doaj   +4 more sources

Extrachromosomal Circular DNA: A New Target in Cancer

Frontiers in Oncology, 2022
Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted.
Pan Wu, Pan Wu, Pan Wu, Yuhang Liu, Yuhang Liu, Yuhang Liu, Ruijia Zhou, Ruijia Zhou, Ruijia Zhou, Lingyun Liu, Hongli Zeng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Wenling Zhang, Wenling Zhang, Can Guo, Fuyan Wang, Ming Zhou, Xuyu Zu, Zhaoyang Zeng, Yong Li, Guiyuan Li, He Huang, He Huang, He Huang, Wei Xiong, Wei Xiong, Wei Xiong   +28 more
doaj   +3 more sources

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions [PDF]

Frontiers in Veterinary Science, 2021
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun, Wei Sun   +6 more
doaj   +4 more sources

Deciphering extrachromosomal circular DNA in Arabidopsis

Computational and Structural Biotechnology Journal, 2021
Extrachromosomal circular DNA (eccDNA) is independent of the chromosome and exists in many eukaryotes. However, the nature and origin of eccDNA in plants remains unclear.
Keyi Wang, Hui Tian, Lequn Wang, Lin Wang, Yacong Tan, Ziting Zhang, Kai Sun, Meng Yin, Qinggong Wei, Baohua Guo, Jinyu Han, Peiru Zhang, Han Li, Yulong Liu, Hongwei Zhao, Xiaoyong Sun   +15 more
doaj   +3 more sources

Extrachromosomal circular DNA: Current status and future prospects

eLife, 2022
Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.
Yiheng Zhao, Linchan Yu, Shuchen Zhang, Xiangyu Su, Xiang Zhou   +4 more
doaj   +3 more sources

Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health. [PDF]

Mol Cancer
Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing and bioinformatics, the accuracy of eccDNAs detection has significantly improved.
Wang Z, Yu J, Zhu W, Hong X, Xu Z, Mao S, Huang L, Han P, He C, Song C, Xiang X.   +10 more
europepmc   +2 more sources