Results 31 to 40 of about 13,987 (204)

Characterization of Extrachromosomal Circular DNA in Primary and Cisplatin-Resistant High-Grade Serous Ovarian Cancer. [PDF]

Genes (Basel)
Wang Y, Li H, Li Q, Li Y, Wu H, Ge Y, Zhu X, Zheng Z, Sun Z.   +8 more
europepmc   +3 more sources

Extrachromosomal circular DNA containing DTX1 promotes cell growth in hydroquinone-induced malignantly transformed cells by regulating the transcription of DTX1 [PDF]

BMC Cancer
Background Extrachromosomal circular DNA (eccDNA), a novel class of DNA with a circular topological structure, is present in a variety of cancer cells and tissues and may play broad roles in processes ranging from aging to cancer cell heterogeneity ...
Xiaoxuan Ling, Qunfang Jiao, Daifan Lin, Jialong Chen, Yali Han, Jinxue Meng, Bohuan Zhong, He Zhang, Gongda Zhang, Fangling Zhu, Jiheng Qin, Yongdui Ruan, Linhua Liu   +12 more
doaj   +2 more sources

Survey of extrachromosomal circular DNA derived from plant satellite repeats [PDF]

BMC Plant Biology, 2008
Background Satellite repeats represent one of the most dynamic components of higher plant genomes, undergoing rapid evolutionary changes of their nucleotide sequences and abundance in a genome.
Macas Jiří, Koblížková Andrea, Navrátilová Alice   +2 more
doaj   +3 more sources

Corrigendum: Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions [PDF]

Frontiers in Veterinary Science, 2021
Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun, Wei Sun   +6 more
doaj   +2 more sources

Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure. [PDF]

Clin Transl Med
Qian Y, Hong X, Yu Y, Du C, Li J, Yu J, Xiao W, Chen C, Huang D, Zhong T, Li J, Xiang X, Li Z.   +12 more
europepmc   +3 more sources

Gene Amplification and the Extrachromosomal Circular DNA [PDF]

Genes, 2021
Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred to as cytogenetically visible double minutes (DMs), or submicroscopic episome, or to the chromosomal homogeneously staining region (HSR).
openaire   +2 more sources

Extrachromosomal circular DNA as a vehicle to gene transfer in plants. [PDF]

Plant Physiol, 2023
Pereira L, Dunning LT.
europepmc   +3 more sources

Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs [PDF]

NAR Cancer
Abstract Extrachromosomal circular DNAs (eccDNAs) are produced from all regions of the eucaryotic genome. We used inverse PCR of non-B microsatellites capable of forming hairpin, triplex, quadruplex and AT-rich structures integrated at a common ectopic chromosomal site to show that these non-B DNAs generate highly mutagenized eccDNAs ...
Rujuta Yashodhan Gadgil, S. Dean Rider, Resha Shrestha, Venicia Alhawach, David C. Hitch, Michael Leffak   +5 more
  +7 more sources

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +1 more source

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj   +1 more source