Results 31 to 40 of about 40,665 (195)

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance. [PDF]

Clin Exp Med
Extrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has ...
Li Z, Qian D.
europepmc   +2 more sources

Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer

Molecular Cancer, 2021
Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous ...
Xiaoxuan Ling, Yali Han, Jinxue Meng, Bohuan Zhong, Jialong Chen, He Zhang, Jiheng Qin, Jing Pang, Linhua Liu   +8 more
doaj   +2 more sources

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, 2022
Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo   +15 more
doaj   +4 more sources

Identification and characterization of extrachromosomal circular DNA in maternal plasma [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance We observed the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. We found that the plasma eccDNA molecules were longer than their linear counterparts. Among such eccDNA molecules, those of fetal origin were
S. Sin, P. Jiang, J. Deng, Lu Ji, S. Cheng, Anindya Dutta, T. Leung, K. C. Chan, R. Chiu, Y. Lo   +9 more
semanticscholar   +4 more sources

Characterization of Plasma Extrachromosomal Circular DNA in Gouty Arthritis

Frontiers in Genetics, 2022
Objective: Extrachromosomal circular DNA elements (eccDNAs) are known for their broad existence in cells and plasma, which may potentially play important roles in many biological processes. Our aim was to identify potentially functional or marked eccDNAs
Jingyuan Pang, Xiaoguang Pan, Ling Lin, Lei Li, Lei Li, Shuai Yuan, Peng Han, Xiaopeng Ji, Hailong Li, Hailong Li, Can Wang, Zhaobin Chu, Zhaobin Chu, Haoru Wu, Guangyi Fan, Guangyi Fan, Xiao Du, Xiao Du, Aichang Ji, Aichang Ji   +19 more
doaj   +3 more sources

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2-Mediated Transcriptional Network in Multiple Myeloma. [PDF]

Adv Sci (Weinh)
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Chen B, Liu J, Zhang Y, Shi C, Zhu D, Zhang G, Xiao F, Zhong L, Zhang M, Ng LG, Huang H, Lu T, Hou J.   +12 more
europepmc   +2 more sources

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

Nature Communications, 2023
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identification, their ...
Xuyuan Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu, Chen Jiang, Jingwen Fang, Shouzhen Li, Yanbing Hou, C. Guo, Kun Qu   +10 more
semanticscholar   +4 more sources

Predicting gestational diabetes mellitus risk at 11-13 weeks' gestation: the role of extrachromosomal circular DNA. [PDF]

Cardiovasc Diabetol
Background Gestational diabetes mellitus (GDM) significantly impacts maternal and infant health both immediately and over the long term, yet effective early diagnostic biomarkers are currently lacking.
Wang J, Huang P, Hou F, Hao D, Li W, Jin H.   +5 more
europepmc   +2 more sources

Identification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract. [PDF]

Epigenetics, 2023
To explore the presence of extrachromosomal circular DNA (eccDNA) in the anterior capsule of the lens in the eyes of patients with cataract and with high myopia.
Wen K, Zhang L, Cai Y, Teng H, Liang J, Yue Y, Li Y, Huang Y, Liu M, Zhang Y, Wei R, Sun J.   +11 more
europepmc   +2 more sources

Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy. [PDF]

Biol Direct
Background Extrachromosomal circular DNAs (eccDNAs) are commonly found in various tumors and play a critical role in promoting oncogenesis. However, little is known about the characteristics and nature of eccDNAs in human heart failure.
Lin Z, Dai F, Li B, Zhao Y, Wang C.
europepmc   +2 more sources