Results 41 to 50 of about 40,665 (195)

Beyond the Chromosome: Recent Developments in Decoding the Significance of Extrachromosomal Circular DNA (eccDNA) in Human Malignancies. [PDF]

Life (Basel)
Extrachromosomal circular DNA (eccDNA) is a form of a circular double-stranded DNA that exists independently of conventional chromosomes. eccDNA exhibits a broad and random distribution across eukaryotic cells and has been associated with tumor-related ...
Tsiakanikas P, Athanasopoulou K, Darioti IA, Agiassoti VT, Theocharis S, Scorilas A, Adamopoulos PG.   +6 more
europepmc   +2 more sources

Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis. [PDF]

Cell Mol Biol Lett
Background Extrachromosomal circular DNA (eccDNA), a kind of circular DNA that originates from chromosomes, carries complete gene information, particularly the oncogenic genes.
Jin W, Xu Z, Song Y, Chen F.
europepmc   +2 more sources

Long extrachromosomal circular DNA identification by fusing sequence-derived features of physicochemical properties and nucleotide distribution patterns. [PDF]

Sci Rep
Long extrachromosomal circular DNA (leccDNA) regulates several biological processes such as genomic instability, gene amplification, and oncogenesis. The identification of leccDNA holds significant importance to investigate its potential associations ...
Abbasi AF, Asim MN, Ahmed S, Dengel A.
europepmc   +2 more sources

Extrachromosomal circular DNA: enlightenment to widespread clinical application

Holistic Integrative Oncology
Shun Wang, Hongrui Li, Yi Zhang, Jian Yan, Wenbin Li   +4 more
doaj   +3 more sources

Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors [PDF]

Stem Cell Research & Therapy, 2023
Background The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have shown that extrachromosomal circular DNAs (eccDNAs) are associated with tumor progression and cell aging, but the roles of ...
Sen Ren, Du Wu, Xiaoyong Shen, Qian Wu, Chengcheng Li, Hewei Xiong, Zhongwei Xiong, Rui Gong, Zheng Liu, Wei Wang, Jincao Chen   +10 more
doaj   +2 more sources

Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease. [PDF]

Clin Transl Med
The accurate diagnosis of cancerous nodules in nodular thyroid disease remains a significant challenge. 1,2 Extra-chromosomal circular DNA (eccDNA), generated during apoptosis, shows tissue/plasma-specific patterns, and varying spectra in different ...
Zhou M, Lv W, Lv W, Han P, Sun K, Hao Z, Gao L, Xu Y, Xu Z, Shao S, Ma S, Guo Q, Zhang H, Liu K, Yang F, Yuan Z, Wu G, Yu C, Luo Y, Yao Z, Zhao J.   +20 more
europepmc   +2 more sources

Characterization and identification of extrachromosomal circular DNA in cholangiocarcinoma

PLOS One
Extrachromosomal circular DNAs (eccDNAs) have gained attention as key players in cancer heterogeneity, potentially associated with elevated oncogene copy numbers in many cancers. While the presence of eccDNA in both normal and cancer cells is confirmed, its influence on gene-level alterations in cancer cells remains largely unexplored.
Zar Zar Win, Hasaya Dokduang, Siriyakorn Kulwong, Watcharin Loilome, Nisana Namwat, Jutarop Phetcharaburanin, Thidathip Wongsurawat, Piroon Jenjaroenpun, Poramate Klanrit, Arporn Wangwiwatsin   +9 more
openalex   +3 more sources

Circle-map profiling of extrachromosomal circular DNA as diagnostic biomarkers for lung cancer. [PDF]

Precis Clin Med
their c har acteristics and genomic landscape . T hough with distinct expression signatures, eccDNA can be present in lung cancer and healthy human plasma.
Yang Y, Song T, Liu S, Liu Z, Wang X, Li Y, Liu D.   +6 more
europepmc   +2 more sources

What Is Extrachromosomal Circular DNA and What Does It Do? [PDF]

Clinical Chemistry, 2020
Rossa W. K. Chiu, Anindya Dutta, Anton G. Henssen, Y. M. Dennis Lo, Paul S. Mischel, Birgitte Regenberg   +5 more
openalex   +4 more sources

Extrachromosomal circular DNA (eccDNA) characteristics in the bile and plasma of advanced perihilar cholangiocarcinoma patients and the construction of an eccDNA-related gene prognosis model. [PDF]

Front Cell Dev Biol
Extrachromosomal DNAs (eccDNAs) frequently carry amplified oncogenes. This investigation aimed to examine the occurrence and role of eccDNAs in individuals diagnosed with advanced perihilar cholangiocarcinoma (pCCA) who exhibited distinct prognostic ...
Fu S, Dai Y, Zhang P, Zheng K, Cao G, Xu L, Zhong Y, Niu C, Wang X.   +8 more
europepmc   +2 more sources