Results 41 to 50 of about 13,987 (204)

Extrachromosomal circular DNA-related SPOCK1 contributes to development and enzalutamide resistance of prostate cancer by regulating epithelial mesenchymal transition. [PDF]

Heliyon
Yao Y, Wang Q, Jiang W, Li H, Li X, Zi T, Qin X, Zhao Y, Wu D, Wu G.   +9 more
europepmc   +2 more sources

Extrachromosomal circular DNA in cancer: history, current knowledge, and methods [PDF]

Trends in Genetics, 2022
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which ...
Noer, Julie B., Hørsdal, Oskar K., Xiang, Xi, Luo, Yonglun, Regenberg, Birgitte   +4 more
openaire   +4 more sources

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Journal of Hematology & Oncology, 2020
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types.
Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu   +7 more
doaj   +1 more source

Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

eLife, 2023
The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis.
Jun Hu, Zhe Zhang, Sai Xiao, Yalei Cao, Yinghong Chen, Jiaming Weng, Hui Jiang, Wei Li, Jia-Yu Chen, Chao Liu   +9 more
doaj   +1 more source

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications. [PDF]

Cell Prolif
ABSTRACTExtrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Li J, Luo P, Li Z, Wang Q, Huang X, Huang X, Wang K, Wang R, Chen R.   +8 more
europepmc   +3 more sources

Extrachromosomal circular DNA is common in yeast [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance We performed a screen for extrachromosomal circular DNAs containing segments of genomic yeast DNA. We found 1,756 such extrachromosomal circular DNAs containing about 23% of the total yeast genomic information. The abundance of these circular forms of genomic DNA suggests that eccDNA formation might be a common mutation that can ...
Møller, Henrik D., Parsons, Lance, Jørgensen, Tue Sparholt, Botstein, David, Regenberg, Birgitte   +4 more
openaire   +3 more sources

Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing

Frontiers in Genetics, 2022
Occurrence of extra-chromosomal circular DNA is a phenomenon frequently observed in tumor cells, and the presence of such DNA has been recognized as a marker of adverse outcome across cancer types.
Alicia Isabell Tüns, Till Hartmann, Simon Magin, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Sven Rahmann, Alexander Schramm, Johannes Köster   +15 more
doaj   +1 more source

Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. [PDF]

PLoS Genetics, 2014
Extrachromosomal DNA amplification is frequent in the protozoan parasite Leishmania selected for drug resistance. The extrachromosomal amplified DNA is either circular or linear, and is formed at the level of direct or inverted homologous repeated ...
Marie-Claude N Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson, Marc Ouellette   +5 more
doaj   +1 more source

Complete genome sequence of Halorhabdus utahensis type strain (AX-2). [PDF]

, 2009
Halorhabdus utahensis Wainø et al. 2000 is the type species of the genus, which is of phylogenetic interest because of its location on one of the deepest branches within the very extensive euryarchaeal family Halobacteriaceae. H.
Anderson, Iain, Brettin, Thomas, Bristow, Jim, Bruce, David, Chain, Patrick, Chang, Yun-Juan, Chen, Amy, Chen, Feng, Cheng, Jan-Fang, Chertkov, Olga, Copeland, Alex, Detter, John C, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Nolan, Matt, Ovchinnikova, Galina, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Pomrenke, Helga, Rohde, Manfred, Tice, Hope, Tindall, Brian J   +36 more
core   +2 more sources

Extrachromosomal circular ribosomal DNA in the yeast Saccharomyces carlsbergensis [PDF]

Nucleic Acids Research, 1979
Purified ribosomal DNA from Saccharomyces carlsbergensis contains a small proportion of circular DNA molecules with a contour length of 3 micron or integral multiples thereof. Hybridization of yeast ribosomal DNA with 26 S rRNA, using the R-loop technique, reveals that these circular molecules contain sequences complementary to yeast ribosomal RNA.
Meyerink, J. H., Klootwijk, J., Planta, R. J., van der Ende, A., van Bruggen, E. F.   +4 more
openaire   +3 more sources