Results 51 to 60 of about 40,665 (195)

Molecular mechanisms of extrachromosomal circular DNA formation. [PDF]

Nucleic Acids Res
Abstract Recent research reveals that eukaryotic genomes form circular DNA from all parts of their genome, some large enough to carry whole genes. In organisms like yeast and in human cancers, it is often observed that extrachromosomal circular DNA (eccDNA) benefits the individual cell by providing resources for rapid cellular growth ...
Eugen-Olsen RAB, Hariprakash JM, Oestergaard VH, Regenberg B.   +3 more
europepmc   +4 more sources

Extrachromosomal circular DNA in cancer: history, current knowledge, and methods. [PDF]

Trends in Genetics, 2022
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which ...
J. Noer, Oskar K. Hørsdal, Xi Xiang, Yonglun Luo, Birgitte Regenberg   +4 more
semanticscholar   +5 more sources

The landscape of extrachromosomal circular DNA in medulloblastoma [PDF]

, 2021
SUMMARYExtrachromosomal circular DNA (ecDNA) is an important driver of aggressive tumor growth, promoting high oncogene copy number, intratumoral heterogeneity, accelerated evolution of drug resistance, enhancer rewiring, and poor outcome. ecDNA has been reported in medulloblastoma (MB), the most common malignant pediatric brain tumor, but the ecDNA ...
Edwin F. Juarez, Sunita Sridhar, Yingxi Lin, Jesse R. Dixon, Sameena Wani, Vineet Bafna, Siavash R. Dehkordi, Ashutosh Tiwari, Michael J. Levy, Joshua T. Lange, Robert J. Wechsler-Reya, Ernest Fraenkel, Ernest Fraenkel, Denise M. Malicki, James T. Robinson, James T. Robinson, Jens Luebeck, Meghana Pagadala, Scott L. Pomeroy, Scott L. Pomeroy, Scott L. Pomeroy, Owen Chapman, Paul S. Mischel, Jeremy N. Rich, John Robertson Crawford, Hannah Carter, Ivy Tsz-Lo Wong, Jon D. Larson, Lukas Chavez, Nicole G. Coufal, Sahaana Chandran, Richard H. Scheuermann, Miriam Adam, Jill P. Mesirov, Shanqing Wang   +34 more
openaire   +1 more source

Extrachromosomal circular DNA as a vehicle to gene transfer in plants. [PDF]

Plant Physiol, 2023
Pereira L, Dunning LT.
europepmc   +3 more sources

Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants

Nature Communications, 2023
Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic regulations and what is its impact on the genome is understudied.
Panpan Zhang, Assane Mbodj, Abirami Soundiramourtty, Christel Llauro, A. Ghesquière, M. Ingouff, R. Keith Slotkin, Frédéric Pontvianne, M. Catoni, Marie Mirouze   +9 more
semanticscholar   +1 more source

Extrachromosomal circular DNA is common in yeast [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance We performed a screen for extrachromosomal circular DNAs containing segments of genomic yeast DNA. We found 1,756 such extrachromosomal circular DNAs containing about 23% of the total yeast genomic information. The abundance of these circular forms of genomic DNA suggests that eccDNA formation might be a common mutation that can ...
Møller, Henrik D., Parsons, Lance, Jørgensen, Tue Sparholt, Botstein, David, Regenberg, Birgitte   +4 more
openaire   +3 more sources

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Journal of Hematology & Oncology, 2020
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types.
Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu   +7 more
doaj   +1 more source

Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

eLife, 2023
The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis.
Jun Hu, Zhe Zhang, Sai Xiao, Yalei Cao, Yinghong Chen, Jiaming Weng, Hui Jiang, Wei Li, Jia-Yu Chen, Chao Liu   +9 more
doaj   +1 more source

Identification and characterization of extrachromosomal circular DNA in age-related osteoporosis. [PDF]

Aging (Albany NY), 2023
Abstract Extrachromosomal circular DNA (eccDNA) was once thought to mainly exist in tumour cells, although it was later shown to be ubiquitous in healthy tissues as well. However, the characteristics and properties of eccDNA in healthy tissue or non-cancer tissue are not well understood.
Zhu Q, Chen R, Kuang M, Zhang W, Wang D, Han S.   +5 more
europepmc   +3 more sources

Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing

Frontiers in Genetics, 2022
Occurrence of extra-chromosomal circular DNA is a phenomenon frequently observed in tumor cells, and the presence of such DNA has been recognized as a marker of adverse outcome across cancer types.
Alicia Isabell Tüns, Till Hartmann, Simon Magin, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Sven Rahmann, Alexander Schramm, Johannes Köster   +15 more
doaj   +1 more source