Results 51 to 60 of about 13,987 (204)

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development

Chinese Journal of Lung Cancer, 2020
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG, Fan YE, Xiao ZHANG, Ruihan ZOU, Mingyuan WANG, Kai YU, Shiyun CUI   +6 more
doaj   +1 more source

Extrachromosomal DNA in Genome (in)Stability – Role of Telomeres [PDF]

, 2016
Eukaryotic genome consists of long linear chromosomes. It is complex in its content and has dynamic features. It mostly consists of non-coding DNA of various repeats, often prone to recombination including creation of extrachromosomal DNA which can be re-
Nanić, Lucia, Ravlić, Sanda, Rubelj, Ivica   +2 more
core   +3 more sources

Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei

Cells, 2019
Extrachromosomal DNA exists in two forms: Covalently closed circular and linear. While diverse types of circular extrachromosomal DNA have been identified with validated in vivo functions, little is known about linear extrachromosomal DNA. In this study,
Teng Sun, Kun Wang, Cuiyun Liu, Yin Wang, Jianxun Wang, Peifeng Li   +5 more
doaj   +1 more source

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]

, 2018
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Nguyen, Nam-Phuong D   +4 more
core   +1 more source

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

Transformation of the Methylotrophic Actinomycete Amycolatopis methanolica with Plasmid DNA: Stimulatory Effect of a pMEA300-Encoded Gene [PDF]

, 1995
Amycolatopsis methanolica contains a 13.29-kb plasmid (pMEA300) present both in the free state and integrated at a unique genomic location. A pMEA300-free derivative (strain WV1) was selected, allowing further analysis of pMEA300-encoded functions. Whole
Dijkhuizen, L.,, Madoń, J.,, Vrijbloed, J.W.,   +2 more
core   +2 more sources

Identification and characterization of extrachromosomal circular DNA in large-artery atherosclerotic stroke. [PDF]

J Cell Mol Med
Chen K, Chi Y, Cheng H, Yang M, Tan Q, Hao J, Lin Y, Mao F, He S, Yang J.   +9 more
europepmc   +3 more sources

Telomere damage induces internal loops that generate telomeric circles

Nature Communications, 2020
Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate ...
Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini, Michele Giannattasio, Fabio Pessina, Ylli Doksani   +6 more
doaj   +1 more source

Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis [PDF]

, 2013
A major goal of current cancer research is to understand the functional consequences of mutations in recombinational DNA repair genes. The introduction of artificial recombination substrates into living cells has evolved into a powerful tool to perform ...
Powell, Simon N., Willers, Henning, Xia, Fen   +2 more
core   +1 more source