Results 61 to 70 of about 13,987 (204)

The landscape of extrachromosomal circular DNA in medulloblastoma [PDF]

, 2021
SUMMARYExtrachromosomal circular DNA (ecDNA) is an important driver of aggressive tumor growth, promoting high oncogene copy number, intratumoral heterogeneity, accelerated evolution of drug resistance, enhancer rewiring, and poor outcome. ecDNA has been reported in medulloblastoma (MB), the most common malignant pediatric brain tumor, but the ecDNA ...
Owen S Chapman, Jens Luebeck, Sameena Wani, Ashutosh Tiwari, Meghana Pagadala, Shanqing Wang, Jon D Larson, Joshua T Lange, Ivy Tsz-Lo Wong, Siavash R Dehkordi, Sahaana Chandran, Miriam Adam, Yingxi Lin, Edwin Juarez, James T Robinson, Sunita Sridhar, Denise M Malicki, Nicole Coufal, Michael Levy, John R Crawford, Scott L Pomeroy, Jeremy Rich, Richard H Scheuermann, Hannah Carter, Jesse Dixon, Paul S Mischel, Ernest Fraenkel, Robert J Wechsler-Reya, Vineet Bafna, Jill P Mesirov, Lukas Chavez   +30 more
openaire   +1 more source

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining [PDF]

, 2006
The tumor suppressor gene BRCA1 maintains genomic integrity by protecting cells from the deleterious effects of DNA double-strand breaks (DSBs).
Chung, J.H., Gent, D.C. (Dik) van, Hallahan, D.E., Powell, S.N., Wang, H. (Hong), Willers, H., Xia, F., Zhang, J. (Shuzhong), Zhuang, J.   +8 more
core   +1 more source

Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer

Molecular Cancer, 2021
Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous ...
Xiaoxuan Ling, Yali Han, Jinxue Meng, Bohuan Zhong, Jialong Chen, He Zhang, Jiheng Qin, Jing Pang, Linhua Liu   +8 more
doaj   +1 more source

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Clinical and Translational Discovery, 2023
Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and ...
Yuchen Zeng, Anqi Wang, Wei Lv, Qingqing Wang, Shiqi Jiang, Xiaoguang Pan, Fei Wang, Huanming Yang, Lars Bolund, Chunhua Lin, Peng Han, Yonglun Luo   +11 more
doaj   +1 more source

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma [PDF]

Nature Genetics, 2019
Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of extrachromosomal circular DNA have not yet been profiled extensively. Here, we combine genomic and transcriptomic approaches to describe the landscape of extrachromosomal circular DNA in neuroblastoma, a ...
Richard P. Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C. MacArthur, Jesper Maag, Rocio Chamorro, Natalia Munoz-Perez, Montserrat Puiggròs, Heathcliff Dorado Garcia, Yi Bei, Claudia Röefzaad, Victor Bardinet, Annabell Szymansky, Annika Winkler, Theresa Thole, Natalie Timme, Katharina Kasack, Steffen Fuchs, Filippos Klironomos, Nina Thiessen, Eric Blanc, Karin Schmelz, Annette Künkele, Patrick Hundsdörfer, Carolina Rosswog, Jessica Theissen, Dieter Beule, Hedwig Deubzer, Sascha Sauer, Joern Toedling, Matthias Fischer, Falk Hertwig, Roland F. Schwarz, Angelika Eggert, David Torrents, Johannes H. Schulte, Anton G. Henssen   +37 more
openaire   +2 more sources

Sequence organization of feline leukemis virus DNA in infected cells [PDF]

, 1980
A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W., Davidson, Norman, Mullins, James I., Nicolson, Margery O.   +3 more
core   +1 more source

Plasmids of Psychrotolerant Polaromonas spp. Isolated From Arctic and Antarctic Glaciers – Diversity and Role in Adaptation to Polar Environments [PDF]

, 2018
Cold-active bacteria of the genus Polaromonas (class Betaproteobacteria) are important components of glacial microbiomes. In this study, extrachromosomal replicons of 26 psychrotolerant Polaromonas strains, isolated from Arctic and Antarctic glaciers ...
Bartosik, Dariusz, Budzik, Karol, Ciok, Anna, Decewicz, Przemysław, Dziewit, Lukasz, Gawor, Jan, Gromadka, Robert, Grzesiak, Jakub, Zdanowski, Marek K   +8 more
core   +8 more sources

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance. [PDF]

Clin Exp Med
AbstractExtrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers.
Li Z, Qian D.
europepmc   +3 more sources

Extrachromosomal Circular DNAs: Origin, formation and emerging function in Cancer [PDF]

International Journal of Biological Sciences, 2021
The majority of cellular DNAs in eukaryotes are organized into linear chromosomes. In addition to chromosome DNAs, genes also reside on extrachromosomal elements. The extrachromosomal DNAs are commonly found to be circular, and they are referred to as extrachromosomal circular DNAs (eccDNAs). Recent technological advances have enriched our knowledge of
Wang, Man, Chen, Xinzhe, Yu, Fei, Ding, Han, Zhang, Yuan, Wang, Kun   +5 more
openaire   +2 more sources

The ICEXTD element from Azoarcus sp. CIB [PDF]

, 2016
35 p.-6 fig.-2 tabIntegrative and conjugative elements (ICE) play a major role in aerobic degradation of aromatic compounds, but they have not yet been shown to be involved in anaerobic degradation.
Díaz, Eduardo, Martín-Moldes, Zaira, Zamarro, María Teresa   +2 more
core   +1 more source