Adaptive dynamics of extrachromosomal circular DNA in rice under nutrient stress
Nature CommunicationsExtrachromosomal circular DNAs (eccDNAs) have been identified in various eukaryotic organisms and are known to play crucial roles in genomic plasticity.
Hanfang Ni +7 more
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Genome-Wide Extrachromosomal Circular DNA Profiling of Paired Hepatocellular Carcinoma and Adjacent Liver Tissues. [PDF]
Cancers (Basel), 2023 Ye J +7 more
europepmc +3 more sources
Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. [PDF]
PLoS Genetics, 2014 Extrachromosomal DNA amplification is frequent in the protozoan parasite Leishmania selected for drug resistance. The extrachromosomal amplified DNA is either circular or linear, and is formed at the level of direct or inverted homologous repeated ...
Marie-Claude N Laffitte +5 more
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Oncogene, 2023 Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery more than half a century ago, emerging as critical driver of tumor evolution.
Yinnan Chen +3 more
semanticscholar +1 more source
Complete genome sequence of Halorhabdus utahensis type strain (AX-2). [PDF]
, 2009 Halorhabdus utahensis Wainø et al. 2000 is the type species of the genus, which is of phylogenetic interest because of its location on one of the deepest branches within the very extensive euryarchaeal family Halobacteriaceae. H.
Anderson, Iain +36 more
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Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development
Chinese Journal of Lung Cancer, 2020 Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG +6 more
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A unifying model for extrachromosomal circular DNA load in eukaryotic cells [PDF]
Seminars in Cell & Developmental Biology, 2022 Extrachromosomal circular DNA (eccDNA) with exons and whole genes are common features of eukaryotic cells. Work from especially tumours and the yeast Saccharomyces cerevisiae has revealed that eccDNA can provide large selective advantages and disadvantages.
Arrey, Gerard +2 more
openaire +3 more sources
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]
, 2018 The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet +4 more
core +1 more source
Extrachromosomal circular ribosomal DNA in the yeast Saccharomyces carlsbergensis [PDF]
Nucleic Acids Research, 1979 Purified ribosomal DNA from Saccharomyces carlsbergensis contains a small proportion of circular DNA molecules with a contour length of 3 micron or integral multiples thereof. Hybridization of yeast ribosomal DNA with 26 S rRNA, using the R-loop technique, reveals that these circular molecules contain sequences complementary to yeast ribosomal RNA.
A Vanderende +4 more
openaire +4 more sources
Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei
Cells, 2019 Extrachromosomal DNA exists in two forms: Covalently closed circular and linear. While diverse types of circular extrachromosomal DNA have been identified with validated in vivo functions, little is known about linear extrachromosomal DNA. In this study,
Teng Sun +5 more
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