Results 71 to 80 of about 40,665 (195)

Extrachromosomal DNA in Genome (in)Stability – Role of Telomeres [PDF]

, 2016
Eukaryotic genome consists of long linear chromosomes. It is complex in its content and has dynamic features. It mostly consists of non-coding DNA of various repeats, often prone to recombination including creation of extrachromosomal DNA which can be re-
Nanić, Lucia, Ravlić, Sanda, Rubelj, Ivica   +2 more
core   +3 more sources

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells [PDF]

, 2016
Extrachromosomal circular DNAs (eccDNAs) are common genetic elements in Saccharomyces cerevisiae and are reported in other eukaryotes as well. EccDNAs contribute to genetic variation among somatic cells in multicellular organisms and to evolution of ...
Bojsen, Rasmus Kenneth, Botstein, David, Møller, Henrik D., Parsons, Lance, Regenberg, Birgitte, Tachibana, Chris   +5 more
core   +2 more sources

Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications

Frontiers in Oncology, 2023
Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability,
Juanjuan Luo, Y. Li, Tangxuan Zhang, Tian Xv, Chao-Hu Chen, Mengting Li, Qixiang Qiu, Y. Song, S. Wan   +8 more
semanticscholar   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

Transformation of the Methylotrophic Actinomycete Amycolatopis methanolica with Plasmid DNA: Stimulatory Effect of a pMEA300-Encoded Gene [PDF]

, 1995
Amycolatopsis methanolica contains a 13.29-kb plasmid (pMEA300) present both in the free state and integrated at a unique genomic location. A pMEA300-free derivative (strain WV1) was selected, allowing further analysis of pMEA300-encoded functions. Whole
Dijkhuizen, L.,, Madoń, J.,, Vrijbloed, J.W.,   +2 more
core   +2 more sources

Extrachromosomal Circular DNAs: Origin, formation and emerging function in Cancer [PDF]

International Journal of Biological Sciences, 2021
The majority of cellular DNAs in eukaryotes are organized into linear chromosomes. In addition to chromosome DNAs, genes also reside on extrachromosomal elements. The extrachromosomal DNAs are commonly found to be circular, and they are referred to as extrachromosomal circular DNAs (eccDNAs). Recent technological advances have enriched our knowledge of
Yuan Zhang, Man Wang, Fei Yu, Kun Wang, Xinzhe Chen, Han Ding   +5 more
openaire   +3 more sources

Telomere damage induces internal loops that generate telomeric circles

Nature Communications, 2020
Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate ...
Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini, Michele Giannattasio, Fabio Pessina, Ylli Doksani   +6 more
doaj   +1 more source

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Clinical and Translational Discovery, 2023
Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and ...
Yuchen Zeng, Anqi Wang, Wei Lv, Qingqing Wang, Shiqi Jiang, Xiaoguang Pan, Fei Wang, Huanming Yang, Lars Bolund, Chunhua Lin, Peng Han, Yonglun Luo   +11 more
doaj   +1 more source

Sequence organization of feline leukemis virus DNA in infected cells [PDF]

, 1980
A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W., Davidson, Norman, Mullins, James I., Nicolson, Margery O.   +3 more
core   +1 more source