Results 71 to 80 of about 13,987 (204)

Sequence-independent identification of active LTR retrotransposons in Arabidopsis [PDF]

, 2018
Detection of retrotransposons capable of contemporary transposition is hampered by the replicative nature of their movement and is usually limited to fortuitous observations of new integration events causing visible phenotypes.
Catoni, M, Griffiths, J, Iwaski, M, Paszkowski, J   +3 more
core   +1 more source

Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma. [PDF]

Theranostics
Rationale: Extrachromosomal circular DNA is a hallmark of cancer, but its role in shaping the genome heterogeneity of urothelial bladder carcinoma (UBC) remains poorly understood. Here, we comprehensively analyzed the features of extrachromosomal circular DNA in 80 UBC patients. Methods: We performed whole-genome/exome sequencing (WGS/WES), Circle-Seq,
Lv W, Pan X, Han P, Wu S, Zeng Y, Wang Q, Guo L, Xu M, Qi Y, Deng L, Xu Z, Li C, Yu T, Cui X, Teng H, Xiang C, Tan H, Li Y, Liang N, Tao H, Gao Q, Yu G, Mi J, Xu F, Gong B, Shi L, Wang T, Yang H, Dong W, Bolund L, Lin L, Wang W, Li H, Huang J, Lin C, Luo Y.   +35 more
europepmc   +4 more sources

Complete genome sequence of Thermaerobacter marianensis type strain (7p75a). [PDF]

, 2010
Thermaerobacter marianensis Takai et al. 1999 is the type species of the genus Thermaerobacter, which belongs to the Clostridiales family Incertae Sedis XVII. The species is of special interest because T.
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Copeland, Alex, Del Rio, Tijana Glavina, Detter, John C, Eisen, Jonathan A, Goodwin, Lynne, Gu, Wei, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Pagani, Ioanna, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Pukall, Rüdiger, Rohde, Manfred, Schneider, Susanne, Tapia, Roxane, Tice, Hope, Woyke, Tanja, Zhang, Xiaojing   +35 more
core   +1 more source

Complete genome sequence of Spirosoma linguale type strain (1). [PDF]

, 2010
Spirosoma linguale Migula 1894 is the type species of the genus. S. linguale is a free-living and non-pathogenic organism, known for its peculiar ringlike and horseshoe-shaped cell morphology. Here we describe the features of this organism, together with
Brettin, Thomas, Bristow, Jim, Bruce, David, Chain, Patrick, Chang, Yun-Juan, Chen, Amy, Chen, Feng, Cheng, Jan-Fang, Copeland, Alex, Detter, John C, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Lail, Kathleen, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Nolan, Matt, Ovchinnikova, Galina, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Saunders, Elizabeth, Schütze, Andrea, Sikorski, Johannes, Tice, Hope, Tindall, Brian J   +36 more
core   +1 more source

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA [PDF]

, 2014
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with epidermal growth factor ...
Cavenee, Webster K., Cloughesy, Timothy F., Eskin, Ascia, Furnari, Frank B., Gini, Beatrice, Gomez, German, Heath, James R., Hwang, Kiwook, James, C. David, Koga, Tomoyuki, Kornblum, Harley I., Masui, Kenta, Mischel, Paul S., Mottahedeh, Jack, Nathanson, David A., Nelson, Stanley F., Ohashi, Minori, Paucar, Andres, Rao, P. Nagesh, Reed, Rachel, Visnyei, Koppany, Wang, Jun, Wykosky, Jill, Yang, Huijun, Zhu, Shaojun   +24 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Identification and characterization of extrachromosomal circular DNA in maternal plasma [PDF]

Proceedings of the National Academy of Sciences, 2020
We explored the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. Through sequencing following either restriction enzyme or Tn5 transposase treatment, we identified eccDNA molecules in the plasma of pregnant women. These eccDNA molecules showed bimodal size distributions peaking at ∼202 and ∼338 bp with distinct 10-bp ...
Sarah T. K. Sin, Peiyong Jiang, Jiaen Deng, Lu Ji, Suk Hang Cheng, Anindya Dutta, Tak Y. Leung, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo   +9 more
openaire   +3 more sources

Mobile circular DNAs regulating memory and communication in CNS neurons

Frontiers in Molecular Neuroscience, 2023
Stimuli that stimulate neurons elicit transcription of immediate-early genes, a process which requires local sites of chromosomal DNA to form double-strand breaks (DSBs) generated by topoisomerase IIb within a few minutes, followed by repair within a few
Neil R. Smalheiser
doaj   +1 more source

Complete genome sequence of Meiothermus silvanus type strain (VI-R2). [PDF]

, 2010
Meiothermus silvanus (Tenreiro et al. 1995) Nobre et al. 1996 belongs to a thermophilic genus whose members share relatively low degrees of 16S rRNA gene sequence similarity.
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Copeland, Alex, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Liolios, Konstantinos, Lowry, Stephen, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Sikorski, Johannes, Tice, Hope, Tindall, Brian J, Woyke, Tanja   +32 more
core   +1 more source