Results 81 to 90 of about 40,665 (195)

Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis [PDF]

, 2013
A major goal of current cancer research is to understand the functional consequences of mutations in recombinational DNA repair genes. The introduction of artificial recombination substrates into living cells has evolved into a powerful tool to perform ...
Powell, Simon N., Willers, Henning, Xia, Fen   +2 more
core   +1 more source

Identification and characterization of extrachromosomal circular DNA in large-artery atherosclerotic stroke. [PDF]

J Cell Mol Med
Chen K, Chi Y, Cheng H, Yang M, Tan Q, Hao J, Lin Y, Mao F, He S, Yang J.   +9 more
europepmc   +3 more sources

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data

Oncogenesis, 2023
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
semanticscholar   +1 more source

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj  

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining [PDF]

, 2006
The tumor suppressor gene BRCA1 maintains genomic integrity by protecting cells from the deleterious effects of DNA double-strand breaks (DSBs).
Chung, J.H., Gent, D.C. (Dik) van, Hallahan, D.E., Powell, S.N., Wang, H. (Hong), Willers, H., Xia, F., Zhang, J. (Shuzhong), Zhuang, J.   +8 more
core   +1 more source

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Science Advances, 2020
EccDNAs are hiding in plain sight in conventional ATAC-seq data. Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells.
Pankaj Kumar, Shashi Kiran, S. Saha, Zhangli Su, Teressa Paulsen, Ajay Chatrath, Y. Shibata, Etsuko Shibata, A. Dutta   +8 more
semanticscholar   +1 more source

Plasmids of Psychrotolerant Polaromonas spp. Isolated From Arctic and Antarctic Glaciers – Diversity and Role in Adaptation to Polar Environments [PDF]

, 2018
Cold-active bacteria of the genus Polaromonas (class Betaproteobacteria) are important components of glacial microbiomes. In this study, extrachromosomal replicons of 26 psychrotolerant Polaromonas strains, isolated from Arctic and Antarctic glaciers ...
Bartosik, Dariusz, Budzik, Karol, Ciok, Anna, Decewicz, Przemysław, Dziewit, Lukasz, Gawor, Jan, Gromadka, Robert, Grzesiak, Jakub, Zdanowski, Marek K   +8 more
core   +8 more sources

Initial Screening of Extrachromosomal Circular DNA Candidates for Pork Meat Quality Traits Using Circle-Seq and RNA-Seq Analysis. [PDF]

Animals (Basel)
Bai L, Wu J, Dou T, Chu D, Li X, Han X, Qiao R, Wang K, Yang F, Li X.   +9 more
europepmc   +2 more sources

Sequence-independent identification of active LTR retrotransposons in Arabidopsis [PDF]

, 2018
Detection of retrotransposons capable of contemporary transposition is hampered by the replicative nature of their movement and is usually limited to fortuitous observations of new integration events causing visible phenotypes.
Catoni, M, Griffiths, J, Iwaski, M, Paszkowski, J   +3 more
core   +1 more source

Plasma extrachromosomal circular DNA is a pathophysiological hallmark of short‐term intensive insulin therapy for type 2 diabetes

Clinical and Translational Medicine, 2023
Background Extrachromosomal circular DNA (eccDNA) has emerged as a promising biomarker for disease diagnosis and prognosis prediction. However, its role in type 2 diabetes remains unexplored.
Zhe Xu, Junyu He, Peng Han, Peiji Dai, Wei Lv, Nian Liu, Liyi Liu, Liehua Liu, Xiaoguang Pan, Xi Xiang, Hanbo Li, Fangfang Ge, Shan Gao, Zhihong Liao, Yonglun Luo, Yanbing Li   +15 more
semanticscholar   +1 more source