Results 1 to 10 of about 2,048,993 (218)

Imaging extrachromosomal DNA (ecDNA) in cancer. [PDF]

Histochem Cell Biol
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring
Purshouse K, Pollard SM, Bickmore WA.
europepmc   +6 more sources

Extrachromosomal DNA in Cancer. [PDF]

Annu Rev Genomics Hum Genet, 2022
In cancer, complex genome rearrangements and other structural alterations, including the amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the formation and progression of tumors.
Bafna V, Mischel PS.
europepmc   +4 more sources

Origins and impact of extrachromosomal DNA. [PDF]

Nature
Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts.
Bailey C, Pich O, Thol K, Watkins TBK, Luebeck J, Rowan A, Stavrou G, Weiser NE, Dameracharla B, Bentham R, Lu WT, Kittel J, Yang SYC, Howitt BE, Sharma N, Litovchenko M, Salgado R, Hung KL, Cornish AJ, Moore DA, Houlston RS, Bafna V, Chang HY, Nik-Zainal S, Kanu N, McGranahan N, Genomics England Consortium, Flanagan AM, Mischel PS, Jamal-Hanjani M, Swanton C.   +30 more
europepmc   +5 more sources

SMC-based immunity against extrachromosomal DNA elements. [PDF]

Biochem Soc Trans, 2023
SMC and SMC-like complexes promote chromosome folding and genome maintenance in all domains of life. Recently, they were also recognized as factors in cellular immunity against foreign DNA.
Liu HW, Roisné-Hamelin F, Gruber S.
europepmc   +5 more sources

Mapping extrachromosomal DNA amplifications during cancer progression. [PDF]

Nat Genet
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson KC, An S, Ko J, Nam Y, Lee HY, Kang S, Chung H, Niclou SP, Moon HE, Paek SH, Bafna V, Luebeck J, Verhaak RGW.   +18 more
europepmc   +5 more sources

Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. [PDF]

Nature, 2023
An analysis of whole-genome sequencing data from patients with Barrett’s oesophagus or oesophageal ademocarcinoma shows that extrachromosomal DNA (ecDNA) is strongly associated with cancer progression, and that a wide range of oncogenes are amplified on ...
Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, Kim H, Jammula S, He Y, Lippman SM, Verhaak RGW, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS.   +19 more
europepmc   +2 more sources

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. [PDF]

Nat Genet, 2023
Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation ...
Chapman OS, Luebeck J, Sridhar S, Wong IT, Dixit D, Wang S, Prasad G, Rajkumar U, Pagadala MS, Larson JD, He BJ, Hung KL, Lange JT, Dehkordi SR, Chandran S, Adam M, Morgan L, Wani S, Tiwari A, Guccione C, Lin Y, Dutta A, Lo YY, Juarez E, Robinson JT, Korshunov A, Michaels JA, Cho YJ, Malicki DM, Coufal NG, Levy ML, Hobbs C, Scheuermann RH, Crawford JR, Pomeroy SL, Rich JN, Zhang X, Chang HY, Dixon JR, Bagchi A, Deshpande AJ, Carter H, Fraenkel E, Mischel PS, Wechsler-Reya RJ, Bafna V, Mesirov JP, Chavez L.   +47 more
europepmc   +2 more sources

Extrachromosomal Circular DNA: A New Target in Cancer [PDF]

Frontiers in Oncology, 2022
Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted.
Pan Wu, Pan Wu, Pan Wu, Yuhang Liu, Yuhang Liu, Yuhang Liu, Ruijia Zhou, Ruijia Zhou, Ruijia Zhou, Lingyun Liu, Hongli Zeng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Wenling Zhang, Wenling Zhang, Can Guo, Fuyan Wang, Ming Zhou, Xuyu Zu, Zhaoyang Zeng, Yong Li, Guiyuan Li, He Huang, He Huang, He Huang, Wei Xiong, Wei Xiong, Wei Xiong   +28 more
doaj   +2 more sources

Modern biology of extrachromosomal DNA: A decade-long voyage of discovery. [PDF]

Cell Res
Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis. A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) — acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size,
Yang QL, Xie Y, Qiao K, Lim JYS, Wu S.
europepmc   +2 more sources

Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications. [PDF]

Front Oncol, 2023
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge ...
Dong Y, He Q, Chen X, Yang F, He L, Zheng Y.   +5 more
europepmc   +2 more sources