Results 1 to 10 of about 2,028,297 (227)

Extrachromosomal DNA in Genome (in)Stability – Role of Telomeres [PDF]

Croatica Chemica Acta, 2016
Eukaryotic genome consists of long linear chromosomes. It is complex in its content and has dynamic features. It mostly consists of non-coding DNA of various repeats, often prone to recombination including creation of extrachromosomal DNA which can be re-
Lucia Nanić, Sanda Ravlić, Ivica Rubelj   +2 more
doaj   +6 more sources

Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics [PDF]

Computational and Structural Biotechnology Journal, 2022
Since the advent of sequencing technologies in the 1990s, researchers have focused on the association between aberrations in chromosomal DNA and disease. However, not all forms of the DNA are linear and chromosomal.
Manrong Wu, Kunal Rai
doaj   +3 more sources

Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. [PDF]

Nature, 2023
An analysis of whole-genome sequencing data from patients with Barrett’s oesophagus or oesophageal ademocarcinoma shows that extrachromosomal DNA (ecDNA) is strongly associated with cancer progression, and that a wide range of oncogenes are amplified on ...
Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, Kim H, Jammula S, He Y, Lippman SM, Verhaak RGW, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS.   +19 more
europepmc   +2 more sources

SMC-based immunity against extrachromosomal DNA elements. [PDF]

Biochem Soc Trans, 2023
SMC and SMC-like complexes promote chromosome folding and genome maintenance in all domains of life. Recently, they were also recognized as factors in cellular immunity against foreign DNA.
Liu HW, Roisné-Hamelin F, Gruber S.
europepmc   +2 more sources

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. [PDF]

Nat Genet, 2023
Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation ...
Chapman OS, Luebeck J, Sridhar S, Wong IT, Dixit D, Wang S, Prasad G, Rajkumar U, Pagadala MS, Larson JD, He BJ, Hung KL, Lange JT, Dehkordi SR, Chandran S, Adam M, Morgan L, Wani S, Tiwari A, Guccione C, Lin Y, Dutta A, Lo YY, Juarez E, Robinson JT, Korshunov A, Michaels JA, Cho YJ, Malicki DM, Coufal NG, Levy ML, Hobbs C, Scheuermann RH, Crawford JR, Pomeroy SL, Rich JN, Zhang X, Chang HY, Dixon JR, Bagchi A, Deshpande AJ, Carter H, Fraenkel E, Mischel PS, Wechsler-Reya RJ, Bafna V, Mesirov JP, Chavez L.   +47 more
europepmc   +2 more sources

Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications. [PDF]

Front Oncol, 2023
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge ...
Dong Y, He Q, Chen X, Yang F, He L, Zheng Y.   +5 more
europepmc   +2 more sources

Studying extrachromosomal DNA with the ecTag method. [PDF]

Nat Rev Cancer, 2022
Yi E.
europepmc   +4 more sources

Extrachromosomal DNA in Cancer. [PDF]

Annu Rev Genomics Hum Genet, 2022
In cancer, complex genome rearrangements and other structural alterations, including the amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the formation and progression of tumors.
Bafna V, Mischel PS.
europepmc   +2 more sources

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes. [PDF]

Cancer Discov, 2023
Small-cell lung cancer is an aggressive neuroendocrine lung cancer. Oncogenic MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC amplification and phenotypic plasticity, characterized by neuroendocrine and non-neuroendocrine ...
Pongor LS, Schultz CW, Rinaldi L, Wangsa D, Redon CE, Takahashi N, Fialkoff G, Desai P, Zhang Y, Burkett S, Hermoni N, Vilk N, Gutin J, Gergely R, Zhao Y, Nichols S, Vilimas R, Sciuto L, Graham C, Caravaca JM, Turan S, Tsai-Wei S, Rajapakse VN, Kumar R, Upadhyay D, Kumar S, Kim YS, Roper N, Tran B, Hewitt SM, Kleiner DE, Aladjem MI, Friedman N, Hager GL, Pommier Y, Ried T, Thomas A.   +36 more
europepmc   +2 more sources

Origins and impact of extrachromosomal DNA. [PDF]

Nature
Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts.
Bailey C, Pich O, Thol K, Watkins TBK, Luebeck J, Rowan A, Stavrou G, Weiser NE, Dameracharla B, Bentham R, Lu WT, Kittel J, Yang SYC, Howitt BE, Sharma N, Litovchenko M, Salgado R, Hung KL, Cornish AJ, Moore DA, Houlston RS, Bafna V, Chang HY, Nik-Zainal S, Kanu N, McGranahan N, Genomics England Consortium, Flanagan AM, Mischel PS, Jamal-Hanjani M, Swanton C.   +30 more
europepmc   +2 more sources