Results 91 to 100 of about 2,028,297 (227)
Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]
, 2003 A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Davidoff, AM +4 more
core +1 more source
Oncogene, 2023 Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery more than half a century ago, emerging as critical driver of tumor evolution.
Yinnan Chen +3 more
semanticscholar +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source
Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
Nature Communications, 2018 Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active ...
Henrik Devitt Møller +11 more
doaj +1 more source
Quantitative Biology, Volume 13, Issue 4, December 2025.Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley +1 more source
How a retrotransposon exploits the plant's heat stress response for its activation.
PLoS Genetics, 2014 Retrotransposons are major components of plant and animal genomes. They amplify by reverse transcription and reintegration into the host genome but their activity is usually epigenetically silenced.
Vladimir V Cavrak +5 more
doaj +1 more source
ApoE gene therapy: an overview and update [PDF]
, 2005 Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core
Public Health Challenges, Volume 4, Issue 3, September 2025.Whole genome insights into diarrhoeagenic Escherichia coli (DEC) strains from Southern Africa → Study focus: Comparative genomics of DEC strains isolated from food, clinical and environmental sources in Southern Africa. Key Findings: 1. High genetic diversity → Region‐specific distribution system observed from association trends between strains from ...
Josphat Gichure, Tina Hald, Elna Buys
wiley +1 more source
Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
Biomarker Research, 2022 Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li +3 more
doaj +1 more source
Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]
, 1997 The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core