Results 91 to 100 of about 2,048,993 (218)

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, Volume 13, Issue 2, 9 January 2026.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

CytoCellDB: A Resource Database For Classification and Analysis of Extrachromosomal DNA in Cancer [PDF]

, 2023
J H Fessler, Stephanie Ting, Hong Yi, Santiago Haase, Jingting Chen, Saygin Gulec, Yue Wang, Nathan Smyers, Kohen Goble, Danielle Cannon, Aarav Mehta, Christina Ford, Elizabeth Brunk   +12 more
openalex   +1 more source

A Growth‐Coupled Evolutionary Strategy Enhances Heme Biosynthesis in Saccharomyces cerevisiae

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Introducing a plasmid with a heme‐responsive promoter connected to a growth‐promoting gene into Saccharomyces cerevisiae created a positive feedback loop between intracellular heme levels and cell growth. After 100 h of adaptive evolution, the plasmid was removed, resulting in a mutant strain that exhibited an ...
Seoyoon Bang, Eunbi Kim, Sehyeon Park, Pil Kim   +3 more
wiley   +1 more source

Molecular mechanisms of extrachromosomal circular DNA formation [PDF]

Nucleic Acids Research
Abstract Recent research reveals that eukaryotic genomes form circular DNA from all parts of their genome, some large enough to carry whole genes. In organisms like yeast and in human cancers, it is often observed that extrachromosomal circular DNA (eccDNA) benefits the individual cell by providing resources for rapid cellular growth ...
Rasmus A B Eugen-Olsen, Judith M Hariprakash, Vibe H Oestergaard, Birgitte Regenberg   +3 more
openaire   +2 more sources

Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype

Cell Reports
Summary: Megabase-sized extrachromosomal circular DNA with intact oncogenes (ecDNA) plays crucial roles in cancer. However, the impact of smaller (100 bp–1 Mb), more ubiquitous extrachromosomal circular DNA (eccDNA) on tumor pathology is unclear.
Peng Han, Wei Lv, Zhe Xu, Tianxi Yu, Shan Gao, Xi Xiang, Xiaoguang Pan, Yuchen Zeng, Jakob Hull Havgaard, Jan Gorodkin, Xue Liang, Shuang Wu, Huiying Tao, Xiaolong Sui, Wenting Wang, Wei Dong, Huanming Yang, Chunhua Lin, Birgitte Regenberg   +18 more
doaj   +1 more source

ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data [PDF]

, 2021
Ludwig Mann, Kathrin M. Seibt, B. Weber, Tony Heitkam   +3 more
openalex   +1 more source

Toward Anti‐Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma‐Associated Herpesvirus Latency‐Associated Nuclear Antigen

ChemMedChem, Volume 21, Issue 1, January 2026.
It is attempted to employ proteolysis‐targeting chimeras‐based targeted protein degradation to the viral protein “Latency‐associated Nuclear Antigen” from Kaposi's sarcoma‐associated herpesvirus. While ternary complex formation is detected via native mass spectrometry, protein degradation is not observed, presumably due to insufficient permeability ...
Aylin Berwanger, Saskia Catherina Stein, Sarah Brandner, Andreas Martin Kany, Sebastian Heinz, Brigitta Loretz, Claus‐Michael Lehr, Anna Katharina Herta Hirsch, Frederik Lermyte, Thomas Friedrich Schulz, Martin Empting   +10 more
wiley   +1 more source

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

eLife
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna   +6 more
doaj   +1 more source

OMIC-01. THE LANDSCAPE OF EXTRACHROMOSOMAL CIRCULAR DNA IN MEDULLOBLASTOMA SUBGROUPS [PDF]

, 2021
Owen Chapman, Jens Luebeck, Shanqing Wang, Alexandra Garancher, Jon D. Larson, Joshua T. Lange, Ivy Tsz Lo Wong, John R. Crawford, Scott L. Pomeroy, Paul S. Mischel, Ernest Fraenkel, Robert J. Wechsler‐Reya, Vineet Bafna, Jill P. Mesirov, Lukas Chávez   +14 more
openalex   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source