Results 101 to 110 of about 2,048,993 (218)
The extrachromosomal circular DNA atlas of aged and young mouse brains
Scientific DataExtrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong +8 more
doaj +1 more source
Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2018 Stably transmitted transgenes are indispensable for labeling cellular components and manipulating cellular functions. In Caenorhabditis elegans, transgenes are generally generated as inheritable multi-copy extrachromosomal arrays, which can be stabilized
Kentaro Noma, Yishi Jin
doaj +1 more source
Effects of nucleases on cell-free extrachromosomal circular DNA
JCI Insight, 2022 Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin +15 more
doaj +1 more source
The genetic architecture and spatiotemporal dynamics of adaptation across human‐modified landscapes
New Phytologist, Volume 249, Issue 2, Page 744-750, January 2026.Summary Understanding the rate and nature of adaptation is crucial for managing biodiversity across our changing landscapes. This perspective synthesizes insights from resistance evolution – a case of rapid, repeated adaptation to extreme human‐mediated selection – to reveal how adaptive genetic architectures determine and feedback with evolutionary ...
Julia M. Kreiner
wiley +1 more source
Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture
Reviews in Aquaculture, Volume 18, Issue 1, January 2026.The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos +7 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract EFSA developed an updated guidance document on the submission of data for the evaluation of the safety and efficacy of decontaminating substances for the removal of microbial surface contamination of foods of animal origin intended for human consumption (referred to as ‘food’).
EFSA Panel on Food Contact Materials (FCM) +22 more
wiley +1 more source
Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes
FEBS Letters, Volume 599, Issue 24, Page 3669-3684, December 2025.The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji +3 more
wiley +1 more source
Methods for the purification and detection of single nucleotide
, 2023 Lasse Bøllehuus Hansen +8 more
openalex +1 more source
Nature Genetics, 2018 To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models derived from them.
A. deCarvalho +18 more
semanticscholar +1 more source
Extrachromosomal nucleic acids in bovine babesia
Memorias do Instituto Oswaldo Cruz, 1992 Two kinds of small extrachromosomal nucleic acid elements were found in the bovine babesias, Babesia bovis and B. bigemina. One element with an apparent size of 5.5 kilobase pairs (kbp) is a double stranded RNA related to virus like particles.
Isidro Hotzel +5 more
doaj +1 more source