Results 11 to 20 of about 2,028,297 (227)

Mapping extrachromosomal DNA amplifications during cancer progression. [PDF]

Nat Genet
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson KC, An S, Ko J, Nam Y, Lee HY, Kang S, Chung H, Niclou SP, Moon HE, Paek SH, Bafna V, Luebeck J, Verhaak RGW.   +18 more
europepmc   +2 more sources

The evolutionary dynamics of extrachromosomal DNA in human cancers. [PDF]

Nat Genet, 2022
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance—random identity by descent—is poorly understood.
Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE, Shi Q, Erb ML, Rajkumar U, Wu S, Taschner-Mandl S, Bernkopf M, Swanton C, Liu Z, Huang W, Chang HY, Bafna V, Henssen AG, Werner B, Mischel PS.   +21 more
europepmc   +2 more sources

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering [PDF]

bioRxiv, 2022
Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosis. It is hypothesized that their copy number, size and
Karin Purshouse, Elias T. Friman, Shelagh Boyle, Pooran Singh Dewari, Vivien Grant, Alhafidz Hamdan, Gillian Morrison, Paul M. Brennan, Sjoerd Viktor Beentjes, Steven M. Pollard, Wendy A. Bickmore   +10 more
openalex   +2 more sources

Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis in Caenorhabditis elegans [PDF]

G3: Genes, Genomes, Genetics, 2018
Stably transmitted transgenes are indispensable for labeling cellular components and manipulating cellular functions. In Caenorhabditis elegans, transgenes are generally generated as inheritable multi-copy extrachromosomal arrays, which can be stabilized
Kentaro Noma, Yishi Jin
doaj   +4 more sources

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. [PDF]

Nat Genet, 2022
CRISPR-CATCH is used to isolate extrachromosomal DNA (ecDNA) molecules containing oncogenes from human cancer cells. CRISPR-CATCH followed by nanopore sequencing allows for methylation profiling, highlighting differences from the native chromosomal loci.
Hung KL, Luebeck J, Dehkordi SR, Colón CI, Li R, Wong IT, Coruh C, Dharanipragada P, Lomeli SH, Weiser NE, Moriceau G, Zhang X, Bailey C, Houlahan KE, Yang W, González RC, Swanton C, Curtis C, Jamal-Hanjani M, Henssen AG, Law JA, Greenleaf WJ, Lo RS, Mischel PS, Bafna V, Chang HY.   +25 more
europepmc   +2 more sources

Examining the cooperation between extrachromosomal DNA circles [PDF]

eLife, 2022
In a departure from previous findings, new results suggest that free-floating pieces of DNA which carry additional copies of cancer-driving genes do not tend to cluster or have increased transcription.
Jiahui Zhang, Cheng-Zhong Zhang
doaj   +2 more sources

Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Journal of Experimental & Clinical Cancer Research, 2020
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse range of cancers.
Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge, Xianqun Fan   +4 more
doaj   +2 more sources

Oncogene Convergence in Extrachromosomal DNA Hubs. [PDF]

Cancer Discov, 2022
Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification.
Weiser NE, Hung KL, Chang HY.
europepmc   +2 more sources

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance. [PDF]

Biochem Soc Trans, 2022
The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples reveal they are common in most cancers and their presence indicates poor prognosis.
Pecorino LT, Verhaak RGW, Henssen A, Mischel PS.   +3 more
europepmc   +2 more sources

Transcription-induced formation of extrachromosomal DNA during yeast ageing.

PLoS Biology, 2019
Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the pathology of cancer and ageing.
Ryan M Hull, Michelle King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan Houseley   +5 more
doaj   +2 more sources