Results 11 to 20 of about 2,048,993 (218)

Extrachromosomal DNA amplifications in cancer. [PDF]

Nat Rev Genet, 2022
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse patient outcome. The functional impact of ecDNA has been linked to its unique properties, such as its circular structure that is associated with altered chromatinization and epigenetic regulatory
Yi E, Chamorro González R, Henssen AG, Verhaak RGW.   +3 more
europepmc   +7 more sources

Gene regulation on extrachromosomal DNA. [PDF]

Nat Struct Mol Biol, 2022
Oncogene amplification on extrachromosomal DNA (ecDNA) is prevalent in human cancer and is associated with poor outcomes. Clonal, megabase-sized circular ecDNAs in cancer are distinct from nonclonal, small sub-kilobase-sized DNAs that may arise during normal tissue homeostasis. ecDNAs enable profound changes in gene regulation beyond copy-number gains.
Hung KL, Mischel PS, Chang HY.
europepmc   +4 more sources

Deciphering extrachromosomal circular DNA in Arabidopsis

Computational and Structural Biotechnology Journal, 2021
Extrachromosomal circular DNA (eccDNA) is independent of the chromosome and exists in many eukaryotes. However, the nature and origin of eccDNA in plants remains unclear.
Keyi Wang, Hui Tian, Lequn Wang, Lin Wang, Yacong Tan, Ziting Zhang, Kai Sun, Meng Yin, Qinggong Wei, Baohua Guo, Jinyu Han, Peiru Zhang, Han Li, Yulong Liu, Hongwei Zhao, Xiaoyong Sun   +15 more
doaj   +3 more sources

Oncogene Convergence in Extrachromosomal DNA Hubs

Cancer Discovery, 2022
Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification.
Natasha E Weiser, King L. Hung, Howard Y. Chang   +2 more
semanticscholar   +3 more sources

Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Journal of Experimental & Clinical Cancer Research, 2020
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse range of cancers.
Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge, Xianqun Fan   +4 more
doaj   +2 more sources

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions [PDF]

Frontiers in Veterinary Science, 2021
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun, Wei Sun   +6 more
doaj   +2 more sources

Examining the cooperation between extrachromosomal DNA circles

eLife, 2022
In a departure from previous findings, new results suggest that free-floating pieces of DNA which carry additional copies of cancer-driving genes do not tend to cluster or have increased transcription.
Jiahui Zhang, Cheng-Zhong Zhang
doaj   +3 more sources

The role of extrachromosomal DNA in tumorigenesis and progression [PDF]

Frontiers in Oncology
In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells.
Xiaoyang Ma, Xiaoyang Ma, Xiaolin Yu, Xiaolin Yu, Chuan Wu, Chuan Wu, Lixing Song, Lixing Song   +7 more
doaj   +2 more sources

Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer. [PDF]

Nat Commun
The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical and molecular features in multiple cohorts ...
Wang S, Wu CY, He MM, Yong JX, Chen YX, Qian LM, Zhang JL, Zeng ZL, Xu RH, Wang F, Zhao Q.   +10 more
europepmc   +2 more sources

Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma. [PDF]

Cancer Discov
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT, Pradella D, Lisi M, Kittel J, Sharma N, Bailey C, Weeden CE, Bell DM, Joo E, Barbè V, Jones MG, Hung KL, Nye EL, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Ventura A, Nicoll JAR, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B.   +34 more
europepmc   +3 more sources