Results 21 to 30 of about 2,028,297 (227)

Gene regulation on extrachromosomal DNA. [PDF]

Nat Struct Mol Biol, 2022
Hung KL, Mischel PS, Chang HY.
europepmc   +2 more sources

Extrachromosomal DNA amplifications in cancer. [PDF]

Nat Rev Genet, 2022
Yi E, Chamorro González R, Henssen AG, Verhaak RGW.   +3 more
europepmc   +2 more sources

Dynamics of extrachromosomal circular DNA in rice

Nature Communications
The genome’s dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu   +10 more
doaj   +2 more sources

Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus [PDF]

, 2022
Luebeck J, Tian Ng AW, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn A, Kim H, Jammula S, He Y, Lippman SM, Verhaak R, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS.   +19 more
europepmc   +2 more sources

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +1 more source

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Journal of Hematology & Oncology, 2020
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types.
Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu   +7 more
doaj   +1 more source

TeCD: The eccDNA Collection Database for extrachromosomal circular DNA

BMC Genomics, 2023
Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo, Ze Zhang, Qingcui Li, Xiao Chang, Xiaoping Liu   +4 more
doaj   +1 more source

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer.

Cancer Discovery, 2021
Oncogenic extrachromosomal DNA elements (ecDNAs) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models and
Eunhee Yi, A. Gujar, Molly Guthrie, Hoon Kim, Dacheng Zhao, K. Johnson, S. Amin, Megan L Costa, Qianru Yu, Sunit Das, Nathaniel Jillette, P. A. Clow, A. Cheng, R. Verhaak   +13 more
semanticscholar   +1 more source

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

Cell Death and Disease, 2022
Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasis of hypopharyngeal squamous cell carcinoma (HSCC).
Changwei Lin, Yifei Chen, Fan Zhang, Baiying Liu, Canbin Xie, Yexun Song   +5 more
semanticscholar   +1 more source

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

Nature Genetics, 2020
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution1–3; however, its frequency and clinical impact are unclear.
Hoon Kim, Nam Nguyen, Kristen M. Turner, Sihan Wu, A. Gujar, J. Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, S. Amin, E. Yi, F. Menghi, J. Schulte, A. Henssen, Howard Y. Chang, C. Beck, P. Mischel, V. Bafna, R. Verhaak   +19 more
semanticscholar   +1 more source