Results 21 to 30 of about 2,048,993 (218)

Transcription-induced formation of extrachromosomal DNA during yeast ageing.

PLoS Biology, 2019
Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the pathology of cancer and ageing.
Ryan M Hull, Michelle King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan Houseley   +5 more
doaj   +2 more sources

Dynamics of extrachromosomal circular DNA in rice

Nature Communications
The genome’s dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu   +10 more
doaj   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles [PDF]

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
openalex   +2 more sources

Extrachromosomal DNA in Genome (in)Stability – Role of Telomeres

Croatica Chemica Acta, 2016
Eukaryotic genome consists of long linear chromosomes. It is complex in its content and has dynamic features. It mostly consists of non-coding DNA of various repeats, often prone to recombination including creation of extrachromosomal DNA which can be re-
Lucia Nanić, Sanda Ravlić, Ivica Rubelj   +2 more
doaj   +2 more sources

Extrachromosomal circular DNA: enlightenment to widespread clinical application [PDF]

Holistic Integrative Oncology
Shun Wang, Hongrui Li, Yi Zhang, Jian Yan, Wenbin Li   +4 more
doaj   +2 more sources

Extrachromosomal DNA in the Apicomplexa. [PDF]

Microbiology and molecular biology reviews : MMBR, 1997
Malaria and related apicomplexan parasites have two highly conserved organellar genomes: one is of plastid (pl) origin, and the other is mitochondrial (mt). The organization of both organellar DNA molecules from the human malaria parasite Plasmodium falciparum has been determined, and they have been shown to be tightly packed with genes.
R J, Wilson, D H, Williamson
openaire   +3 more sources

STEM-07. CONSERVATION AND FAITHFUL REPRESENTATION OF CIRCULAR EXTRACHROMOSOMAL DNA IN ORTHOTOPIC PATIENT-DERIVED MEDULLOBLASTOMA XENOGRAFTS [PDF]

Neuro Oncol
Rishaan Kenkre, Owen Chapman, Jens Luebeck, Vineet Bafna, Robert J. Wechsler‐Reya, Jill P. Mesirov, Lukas Chávez   +6 more
europepmc   +3 more sources

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj   +1 more source

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes.

Cancer Discovery, 2023
Small-cell lung cancer is an aggressive neuroendocrine lung cancer. Oncogenic MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC amplification and phenotypic plasticity, characterized by neuroendocrine and non-neuroendocrine ...
L. Pongor, Christopher W. Schultz, Lorenzo Rinaldi, Darawalee Wangsa, C. Redon, N. Takahashi, Gavriel Fialkoff, Parth Desai, Yang Zhang, S. Burkett, Nadav Hermoni, Noa Vilk, J. Gutin, G. Róna, Yongmei Zhao, Samantha Nichols, R. Vilimas, Linda Sciuto, Chante Graham, J. M. Caravaca, S. Turan, Tsai-wei Shen, V. Rajapakse, Rajesh Kumar, Deep Upadhyay, Suresh Kumar, Yoo Sun Kim, N. Roper, Bao Tran, S. Hewitt, D. Kleiner, M. Aladjem, N. Friedman, G. Hager, Y. Pommier, T. Ried, Anish Thomas   +36 more
semanticscholar   +1 more source

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +1 more source