Results 31 to 40 of about 2,028,297 (227)

Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. [PDF]

PLoS Genetics, 2014
Extrachromosomal DNA amplification is frequent in the protozoan parasite Leishmania selected for drug resistance. The extrachromosomal amplified DNA is either circular or linear, and is formed at the level of direct or inverted homologous repeated ...
Marie-Claude N Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson, Marc Ouellette   +5 more
doaj   +1 more source

Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression

Scientific Reports, 2022
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor ...
Tao Wu, Chenxu Wu, Xiangyu Zhao, Guangshuai Wang, W. Ning, Ziyu Tao, Fuxiang Chen, Xue-song Liu   +7 more
semanticscholar   +1 more source

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development

Chinese Journal of Lung Cancer, 2020
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG, Fan YE, Xiao ZHANG, Ruihan ZOU, Mingyuan WANG, Kai YU, Shiyun CUI   +6 more
doaj   +1 more source

Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

eLife, 2023
The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis.
Jun Hu, Zhe Zhang, Sai Xiao, Yalei Cao, Yinghong Chen, Jiaming Weng, Hui Jiang, Wei Li, Jia-Yu Chen, Chao Liu   +9 more
doaj   +1 more source

Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells. [PDF]

PLoS ONE, 2016
A plasmid bearing both a replication initiation region and a matrix attachment region is spontaneously amplified in transfected mammalian cells and generates plasmid repeats in the extrachromosomal double minutes (DMs) or the chromosomal homogeneously ...
Sho-Hei Mitsuda, Noriaki Shimizu
doaj   +1 more source

Pioneering insights of extrachromosomal DNA (ecDNA) generation, action and its implications for cancer therapy

International Journal on Biological Sciences, 2022
Extrachromosomal DNA (ecDNA) is a cancer-specific circular DNA molecule that is derived from chromosomes. In contrast with linear chromosomes, ecDNA exhibits a unique structure that can be representative of high chromosome accessibility, contributing to ...
Zesheng Li, Bo Wang, Hao Liang, Lei Han
semanticscholar   +1 more source

Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei

Cells, 2019
Extrachromosomal DNA exists in two forms: Covalently closed circular and linear. While diverse types of circular extrachromosomal DNA have been identified with validated in vivo functions, little is known about linear extrachromosomal DNA. In this study,
Teng Sun, Kun Wang, Cuiyun Liu, Yin Wang, Jianxun Wang, Peifeng Li   +5 more
doaj   +1 more source

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]

, 2018
Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi, A Verdina, AC Borisa, AT Lau, B Mierzwa, C Ditchfield, C Lazzari, C Mollinari, C Norden, C Rinaldo, C Rinaldo, C Rinaldo, C Rinaldo, Cinzia Rinaldo, CK Hu, D Valente, Davide Valente, E Gresko, F Siepi, G D’Orazi, G D’Orazi, G Normand, GE Atilla-Gokcumen, H Goto, HC Huang, I Vitale, JA Blaquiere, JM Cummins, JP Fededa, JR Bischoff, K Kobiyama, L Vega De la, Laura Monteonofrio, M Agromayor, M Carmena, M Glotzer, M Kollareddy, Manuela Ferrara, Marco Crescenzi, ME Douglas, ME Douglas, O Afonso, P Carpinelli, PP D’Avino, R Kuriyama, R Nunes Bastos, Roberta Miscione, S Francia, S Hauf, S Matt, Serena Camerini, Silvia Soddu, SM Lens, TD Pollard, TG Hofmann, TG Hofmann, V Bavetsias, VV Saul, VV Saul, WM Zhao, XL Li, Y Feng, Y Kuwano, Y Terada, YH Kim, Z Storchova   +65 more
core   +1 more source

Extrachromosomal DNA: An Emerging Hallmark in Human Cancer.

Annual Review of Pathology, 2021
Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA).
Sihan Wu, V. Bafna, Howard Y. Chang, P. Mischel   +3 more
semanticscholar   +1 more source

Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Clinical Cancer Research, 2021
Purpose: Human papillomavirus (HPV) plays a major role in oncogenesis and circular extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship between HPV and circular ecDNA in human cancer is not understood.
John Pang, Nam Nguyen, J. Luebeck, Laurel L. Ball, A. Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, S. Sadat, P. Mischel, Guorong Xu, K. Fisch, T. Guo, Gabrielle L Cahill, B. Panuganti, V. Bafna, J. Califano   +16 more
semanticscholar   +1 more source