Results 31 to 40 of about 2,048,993 (218)

The evolutionary dynamics of extrachromosomal DNA in human cancers

Nature Genetics, 2022
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance—random identity by descent—is poorly understood.
Joshua T. Lange, John C. Rose, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, K. Yost, Quanming Shi, M. Erb, Utkrisht Rajkumar, Sihan Wu, S. Taschner-Mandl, M. Bernkopf, C. Swanton, Zhe J. Liu, Weini Huang, Howard Y. Chang, V. Bafna, A. Henssen, B. Werner, P. Mischel   +21 more
semanticscholar   +1 more source

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Journal of Hematology & Oncology, 2020
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types.
Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu   +7 more
doaj   +1 more source

TeCD: The eccDNA Collection Database for extrachromosomal circular DNA

BMC Genomics, 2023
Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo, Ze Zhang, Qingcui Li, Xiao Chang, Xiaoping Liu   +4 more
doaj   +1 more source

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer.

Cancer Discovery, 2021
Oncogenic extrachromosomal DNA elements (ecDNAs) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models and
Eunhee Yi, A. Gujar, Molly Guthrie, Hoon Kim, Dacheng Zhao, K. Johnson, S. Amin, Megan L Costa, Qianru Yu, Sunit Das, Nathaniel Jillette, P. A. Clow, A. Cheng, R. Verhaak   +13 more
semanticscholar   +1 more source

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

Nature Genetics, 2020
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution1–3; however, its frequency and clinical impact are unclear.
Hoon Kim, Nam Nguyen, Kristen M. Turner, Sihan Wu, A. Gujar, J. Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, S. Amin, E. Yi, F. Menghi, J. Schulte, A. Henssen, Howard Y. Chang, C. Beck, P. Mischel, V. Bafna, R. Verhaak   +19 more
semanticscholar   +1 more source

Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. [PDF]

PLoS Genetics, 2014
Extrachromosomal DNA amplification is frequent in the protozoan parasite Leishmania selected for drug resistance. The extrachromosomal amplified DNA is either circular or linear, and is formed at the level of direct or inverted homologous repeated ...
Marie-Claude N Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson, Marc Ouellette   +5 more
doaj   +1 more source

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development

Chinese Journal of Lung Cancer, 2020
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG, Fan YE, Xiao ZHANG, Ruihan ZOU, Mingyuan WANG, Kai YU, Shiyun CUI   +6 more
doaj   +1 more source

Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells. [PDF]

PLoS ONE, 2016
A plasmid bearing both a replication initiation region and a matrix attachment region is spontaneously amplified in transfected mammalian cells and generates plasmid repeats in the extrachromosomal double minutes (DMs) or the chromosomal homogeneously ...
Sho-Hei Mitsuda, Noriaki Shimizu
doaj   +1 more source

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

Cell Death and Disease, 2022
Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasis of hypopharyngeal squamous cell carcinoma (HSCC).
Changwei Lin, Yifei Chen, Fan Zhang, Baiying Liu, Canbin Xie, Yexun Song   +5 more
semanticscholar   +1 more source

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

bioRxiv, 2021
CRISPR-CATCH is used to isolate extrachromosomal DNA (ecDNA) molecules containing oncogenes from human cancer cells. CRISPR-CATCH followed by nanopore sequencing allows for methylation profiling, highlighting differences from the native chromosomal loci.
King L. Hung, J. Luebeck, S. R. Dehkordi, C. Coruh, Julie A. Law, W. Greenleaf, P. Mischel, V. Bafna, Howard Y. Chang   +8 more
semanticscholar   +1 more source