Results 41 to 50 of about 2,028,297 (227)

Isolation of Extrachromosomal Elements by Histone Immunoprecipitation

BioTechniques, 2001
Here, we describe a gentle and effective method for the rapid and reproducible isolation of histone-bound extrachromosomal DNA molecules called extrachromosomal elements (EEs). This method facilitates the harvest of a specific population of EEs following
T.I. Kuschak, B.C. Kuschak, G.M. Smith, J.A. Wright, S. Mai   +4 more
doaj   +1 more source

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Caenorhabditis nomenclature [PDF]

, 2018
Genetic nomenclature allows the genetic features of an organism to be structured and described in a uniform and systematicway. Genetic features, including genes, variations (both natural and induced), and gene products, are assigned descriptorsthat ...
Daul, Aric, Schedl, Tim, Tuli, Mary Ann
core   +2 more sources

RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination [PDF]

, 2001
Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination
Chang, Fu-Chung, Desiderio, Stephen, Li, Wenhui   +2 more
core   +2 more sources

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

bioRxiv, 2021
Background Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read
Weitian Chen, Z. Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li, Chong Tang   +13 more
semanticscholar   +1 more source

In vivo functional genomic studies of sterol carrier protein-2 gene in the yellow fever mosquito. [PDF]

PLoS ONE, 2011
A simple and efficient DNA delivery method to introduce extrachromosomal DNA into mosquito embryos would significantly aid functional genomic studies. The conventional method for delivery of DNA into insects is to inject the DNA directly into the embryos.
Rong Peng, Vilena I Maklokova, Jayadevi H Chandrashekhar, Que Lan   +3 more
doaj   +1 more source

Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

Frontiers in Cell and Developmental Biology, 2022
Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells.
Shanru Zuo, Shanru Zuo, Yihu Yi, Chen Wang, Xueguang Li, Mingqing Zhou, Qiyao Peng, Qiyao Peng, Junhua Zhou, Yide Yang, Quanyuan He   +10 more
doaj   +1 more source

Small ring has big potential: insights into extrachromosomal DNA in cancer

Cancer Cell International, 2021
Recent technical advances have led to the discovery of novel functions of extrachromosomal DNA (ecDNA) in multiple cancer types. Studies have revealed that cancer-associated ecDNA shows a unique circular shape and contains oncogenes that are more ...
Yihao Wang, Rui Huang, G. Zheng, Jianfeng Shen   +3 more
semanticscholar   +1 more source

Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2016
Extrachromosomal circular DNA (eccDNA) derived from chromosomal Ty retrotransposons in yeast can be generated in multiple ways. Ty eccDNA can arise from the circularization of extrachromosomal linear DNA during the transpositional life cycle of ...
Henrik D. Møller, Camilla E. Larsen, Lance Parsons, Anders Johannes Hansen, Birgitte Regenberg, Tobias Mourier   +5 more
doaj   +1 more source

Extrachromosomal Circular DNA: A New Target in Cancer

Frontiers in Oncology, 2022
Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted.
Pan Wu, Pan Wu, Pan Wu, Yuhang Liu, Yuhang Liu, Yuhang Liu, Ruijia Zhou, Ruijia Zhou, Ruijia Zhou, Lingyun Liu, Hongli Zeng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Wenling Zhang, Wenling Zhang, Can Guo, Fuyan Wang, Ming Zhou, Xuyu Zu, Zhaoyang Zeng, Yong Li, Guiyuan Li, He Huang, He Huang, He Huang, Wei Xiong, Wei Xiong, Wei Xiong   +28 more
doaj   +1 more source