Results 51 to 60 of about 2,028,297 (227)

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions

Frontiers in Veterinary Science, 2021
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun, Wei Sun   +6 more
doaj   +1 more source

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Nature Communications, 2021
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations
Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang   +18 more
doaj   +1 more source

Extrachromosomal circular DNA: Current status and future prospects

eLife, 2022
Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.
Yiheng Zhao, Linchan Yu, Shuchen Zhang, Xiangyu Su, Xiang Zhou   +4 more
doaj   +1 more source

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]

, 2018
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Nguyen, Nam-Phuong D   +4 more
core   +1 more source

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj  

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Signal Transduction and Targeted Therapy, 2022
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Ludi Yang, Ruobing Jia, Tongxin Ge, Shengfang Ge, Ai Zhuang, Peiwei Chai, Xianqun Fan   +6 more
doaj   +1 more source

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. [PDF]

, 2019
Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and architecture are little
Andrew D. Chisholm, Antonio Colavita, Carr, Chalfie, Chen, Chen, Chen, Coleman, Dickinson, Emoto, Finn, Hammarlund, Hayashi, Jan, Lee, Li, Li, Matter, Mukhopadhyay, Nathaniel Noblett, Nitta, Ouchi, Pan, Sanchez-Alvarez, Schmelz, Seungmee Park, Stephane Flibotte, Tank, Thorvaldsdóttir, Tony Roenspies, Toth, Wu, Yan, Yishi Jin, Zhang, Zhao Hua Ding, Zilu Wu   +36 more
core   +1 more source

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA [PDF]

, 2014
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with epidermal growth factor ...
Cavenee, Webster K., Cloughesy, Timothy F., Eskin, Ascia, Furnari, Frank B., Gini, Beatrice, Gomez, German, Heath, James R., Hwang, Kiwook, James, C. David, Koga, Tomoyuki, Kornblum, Harley I., Masui, Kenta, Mischel, Paul S., Mottahedeh, Jack, Nathanson, David A., Nelson, Stanley F., Ohashi, Minori, Paucar, Andres, Rao, P. Nagesh, Reed, Rachel, Visnyei, Koppany, Wang, Jun, Wykosky, Jill, Yang, Huijun, Zhu, Shaojun   +24 more
core   +2 more sources

Design of a titering assay for lentiviral vectors utilizing direct extraction of DNA from transduced cells in microtiter plates

Molecular Therapy: Methods & Clinical Development, 2016
Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the number of vector DNA copies in ...
Michele E Murphy, Chintan D Vin, Megan M Slough, Wayne R Gombotz, Brenna Kelley-Clarke   +4 more
doaj   +1 more source

Telomere damage induces internal loops that generate telomeric circles

Nature Communications, 2020
Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate ...
Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini, Michele Giannattasio, Fabio Pessina, Ylli Doksani   +6 more
doaj   +1 more source