Results 51 to 60 of about 2,048,993 (218)

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance

Biochemical Society Transactions, 2022
The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples reveal they are common in most cancers and their presence indicates poor prognosis.
L. Pecorino, R. Verhaak, A. Henssen, P. Mischel   +3 more
semanticscholar   +1 more source

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers [PDF]

Tang J, Weiser NE, Wang G, Chowdhry S, Curtis EJ, Zhao Y, Wong IT, Marinov GK, Li R, Hanoian P, Tse E, Hansen R, Plum J, Steffy A, Milutinovic S, Meyer ST, Curtis C, Greenleaf WJ, Bafna V, Benkovic SJ, Pinkerton AB, Kasibhatla S, Hassig CA, Mischel PS, Chang HY.   +24 more
europepmc   +2 more sources

Extrachromosomal DNA - relieving heredity constraints, accelerating tumour evolution. [PDF]

Annals of Oncology, 2020
Oncogene amplification on extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells can rapidly adapt to changes in the tumour microenvironment. These circular structures contain oncogenes and their regulatory elements, and, lacking centromeres, they are subject to unequal segregation during mitosis.
Chris Bailey, M. Shoura, P. Mischel, C. Swanton   +3 more
semanticscholar   +4 more sources

Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

Frontiers in Cell and Developmental Biology, 2022
Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells.
Shanru Zuo, Shanru Zuo, Yihu Yi, Chen Wang, Xueguang Li, Mingqing Zhou, Qiyao Peng, Qiyao Peng, Junhua Zhou, Yide Yang, Quanyuan He   +10 more
doaj   +1 more source

Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Clinical Cancer Research, 2021
Purpose: Human papillomavirus (HPV) plays a major role in oncogenesis and circular extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship between HPV and circular ecDNA in human cancer is not understood.
John Pang, Nam Nguyen, J. Luebeck, Laurel L. Ball, A. Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, S. Sadat, P. Mischel, Guorong Xu, K. Fisch, T. Guo, Gabrielle L Cahill, B. Panuganti, V. Bafna, J. Califano   +16 more
semanticscholar   +1 more source

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Nature Communications, 2021
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations
Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang   +18 more
doaj   +1 more source

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

bioRxiv, 2021
Background Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read
Weitian Chen, Z. Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li, Chong Tang   +13 more
semanticscholar   +1 more source

Extrachromosomal circular DNA: Current status and future prospects

eLife, 2022
Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.
Yiheng Zhao, Linchan Yu, Shuchen Zhang, Xiangyu Su, Xiang Zhou   +4 more
doaj   +1 more source

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Signal Transduction and Targeted Therapy, 2022
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Ludi Yang, Ruobing Jia, Tongxin Ge, Shengfang Ge, Ai Zhuang, Peiwei Chai, Xianqun Fan   +6 more
doaj   +1 more source

Small ring has big potential: insights into extrachromosomal DNA in cancer

Cancer Cell International, 2021
Recent technical advances have led to the discovery of novel functions of extrachromosomal DNA (ecDNA) in multiple cancer types. Studies have revealed that cancer-associated ecDNA shows a unique circular shape and contains oncogenes that are more ...
Yihao Wang, Rui Huang, G. Zheng, Jianfeng Shen   +3 more
semanticscholar   +1 more source