Results 81 to 90 of about 2,028,297 (227)

Extrachromosomal DNA : New Players in Oncology

Asian Journal of Medical Sciences
DNA that is found outside the main chromosomes in a cell's nucleus is known as extrachromosomal DNA. This type of DNA is not part of the standard 23 pairs of chromosomes in humans and instead exists as standalone circular or linear DNA structures. Unlike
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Extrachromosomal Circular DNA: Emerging Insights Into Cardiovascular Disease Mechanisms and Biomarker Potential

iLABMED, EarlyView.
Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan, Jawairya Muhammad Hussain, Surraiya Riaz Mahmood Khan, Bushra Nadeem, Tahniyat Naseem, Hammad Jawed, Aina Lashari   +6 more
wiley   +1 more source

Inactivation of p53 rescues the maintenance of high risk HPV DNA genomes deficient in expression of E6.

PLoS Pathogens, 2013
The human papillomavirus DNA genome undergoes three distinct stages of replication: establishment, maintenance and amplification. We show that the HPV16 E6 protein is required for the maintenance of the HPV16 DNA genome as an extrachromosomal, nuclear ...
Laurel D Lorenz, Jessenia Rivera Cardona, Paul F Lambert   +2 more
doaj   +1 more source

Human Smc5/6 recognises transcription-generated positive DNA supercoils

Nature Communications
Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which is lost upon
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin   +5 more
doaj   +1 more source

Replication of bacterial plasmids in the nucleus of the red alga Porphyridium purpureum

Nature Communications, 2018
Genetic tools for research on red algae (rhodophytes) are lacking. Here, Li and Bock present an efficient genetic transformation system for a model rhodophyte, and show that the transgenic DNA can be maintained as an extrachromosomal multi-copy plasmid ...
Zhichao Li, Ralph Bock
doaj   +1 more source

Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. [PDF]

, 2019
Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates.
Adina Gerson-Gurwitz, Arribere, Arshad Desai, Bahl, Bando, Bies, Brown, Byerly, Cancino, Carolyn A. Worby, Carrascal, Cui, Dhanya Cheerambathur, Erin J. Cram, Fradin, Frøkjaer-Jensen, Gerald, Ghazarian, Gibson, Gorelik, Green, Ishikawa, Jack E. Dixon, Jeff Bouffard, Johnson, Kamath, Karen Oegema, Kian-Yong Lee, Kim, Kimble, Koike, Koob, Kovacevic, Köppen, Leiser, Leiser, Levin, Lindberg, Mann, Manning, Minko, Mody, Nakamura, Paschinger, Petrella, Pollak, Pollard, Pulvirenti, Raine, Reinhart, Renat Khaliullin, Rolls, Salvi, Sievers, Simpson, Sreelatha, Tagliabracci, Tagliabracci, Tagliabracci, Takeuchi, Tseng, Vogel, Wang, Ward, Wen, Wewer, Xiao, Yue, Zhang, Zhou, Zhou   +70 more
core   +2 more sources

Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants

Nature Communications, 2023
Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic regulations and what is its impact on the genome is understudied.
Panpan Zhang, Assane Mbodj, Abirami Soundiramourtty, Christel Llauro, A. Ghesquière, M. Ingouff, R. Keith Slotkin, Frédéric Pontvianne, M. Catoni, Marie Mirouze   +9 more
semanticscholar   +1 more source

Analysis of multiple‐herbicide resistant Amaranthus palmeri populations from Spain points to an introduction of the eccDNA from America

Pest Management Science, EarlyView.
In this study, multiple herbicide resistant mechanisms have been confirmed in two Amaranthus palmeri populations from Spain that survived glyphosate‐ and ALS‐inhibitor herbicides. Our data suggest that the eccDNA and the mutations identified in the ALS gene are the result of an evolutionary event that occurred outside Spain.
Alfredo Manicardi, Germán Mora, André Lucas Simões Araujo, Todd A. Gaines, Jorge Lozano‐Juste, Joel Torra   +5 more
wiley   +1 more source

HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.

PLoS Genetics, 2022
Shotgun metagenomics is a powerful tool to identify antimicrobial resistance (AMR) genes in microbiomes but has the limitation that extrachromosomal DNA, such as plasmids, cannot be linked with the host bacterial chromosome.
Lajos Kalmar, Srishti Gupta, Iain R L Kean, Xiaoliang Ba, Nazreen Hadjirin, Elizabeth M Lay, Stefan P W de Vries, Michael Bateman, Harriet Bartlet, Juan Hernandez-Garcia, Alexander W Tucker, Olivier Restif, Mark P Stevens, James L N Wood, Duncan J Maskell, Andrew J Grant, Mark A Holmes   +16 more
doaj   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source