Results 111 to 120 of about 2,861 (126)

Extrachromosomal inheritance of nalidixic acid resistance in the petite negative yeast Schizosaccharomyces pombe

Molecular and General Genetics MGG, 1982
Spontaneous mutants resistant to nalidixic acid (NAL) were isolated from the petite negative yeast Schizosaccharomyces pombe (S. pombe). One of these mutants, resistant to 200 micrograms/ml NAL, nalr-Y13, was characterized both genetically and biochemically.
D R, Massardo, L, Del Giudice, F, Manna, K, Wolf   +3 more
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Expression and inheritance of the yeast extrachromosomal element ψ do not depend on RNA polymerase I

Current Genetics, 1994
The extrachromosomal element psi affects translation fidelity in the yeast Saccharomyces cerevisiae by increasing the efficiency of tRNA-mediated ochre suppression. The nature of the psi factor is unknown, although there is evidence that 3-microns circles from psi+ strains can be used to transform psi- cells to psi+.
C R, Nierras, B S, Cox
openaire   +2 more sources

Tethered to survive: Mitotic transcription secures faithful inheritance of extrachromosomal DNA

Molecular Cell
In this issue of Molecular Cell, Nichols et al.1 uncover a transcription-dependent tethering mechanism that enables mitotic inheritance of extrachromosomal DNA (ecDNA) in cancer cells, revealing how transcriptionally active ecDNA escapes degradation and drives oncogene persistence through cell division.
Xue, Jin, Roel G W, Verhaak
openaire   +2 more sources

Extrachromosomal forms of CLV DNA1 in transgenic plants are inherited by symptom-free progeny

Plant Science, 1989
Abstract Two full length copies of Cassava latent virus (CLV) DNA1 were cloned in head to tail arrangement on a plant expression vector to evaluate the potential of CLV for the development of an extrachromosomal vector system in plants. After direct transfer of the plasmid into protoplasts of Nicotiana tabacum cv.
Peter Meyer, Ingrid Niedenhof, Iris Heidmann, Heinz Saedler   +3 more
openaire   +1 more source

Abstract 2564: Tracing extrachromosomal DNA inheritance patterns in glioblastoma using CRISPR

Cancer Research, 2019
Abstract Glioblastoma (GBM) is the most lethal brain tumor; it is characterized by poor response to standard post-resection radiation and cytotoxic therapy, resulting in a dismal prognosis with a five-year survival rate of 10%. Recurrence after therapy for GBM is unavoidable.
Eunhee Yi, Roel Verhaak
openaire   +1 more source

Extrachromosomal Inheritance: Yeast Linear Killer Plasmids as a Tool in Genetic Engineering

1995
In principle, every stably replicated DNA species can serve as a vector for cloning foreign DNA in yeast or any other organism, in which such DNA is found. In strains of Saccharomyces cerevisiae a high copy number, autonomously replicating, extrachromosomal DNA element, the 2 µm DNA, was found to exist (Sinclair et al. 1967).
Jürgen Schründer, Friedhelm Meinhardt
openaire   +1 more source

Quantitative models of hybrid dysgenesis: Rapid evolution under transposition, extrachromosomal inheritance, and fertility selection

Theoretical Population Biology, 1985
A model of the P-M system of hybrid dysgenesis is presented which incorporates single-site transposition of P factors in M cytotype, determination of offspring cytotype by both maternal cytotype and maternal or offspring nuclear genotype, and strong fertility selection in dysgenic individuals.
openaire   +2 more sources

Soma to germline inheritance of extrachromosomal genetic information via a LINE‐1 reverse transcriptase‐based mechanism

BioEssays, 2016
Mature spermatozoa are permeable to foreign DNA and RNA molecules. Here I propose a model, whereby extrachromosomal genetic information, mostly encoded in the form of RNA in somatic cells, can cross the Weismann barrier and reach epididymal spermatozoa.
openaire   +4 more sources

[The origin of extrachromosomal inheritance factors (plasmids) in bacteria].

Zhurnal evoliutsionnoi biokhimii i fiziologii, 1994
Present status of the problem of origin of extra-chromosomal inheritance elements is reviewed in the light of literary data and some results obtained by the author. The role of plasmids in the ecology of bacteria, in their adaptive variability and evolution is discussed.
openaire   +1 more source

Extrachromosomal inheritance in bacteria.

Contributions to microbiology and immunology, 1980
openaire   +3 more sources