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Extracorporeal photochemotherapy: A scientific overview

Transfusion Science, 1994
Extracorporeal photochemotherapy was developed for treatment of cutaneous T-cell lymphoma (CTCL). Several independent and multicenter trials using lymphapheresis with 8-methoxypsoralen (8-MOP) activated by shortwave ultraviolet light have demonstrated the clinical benefit of this modality for treatment of advanced CTCL.
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Extracorporeal Photochemotherapy for Drug-Resistant Pemphigus Vulgaris

Annals of Internal Medicine, 1990
Excerpt The extracorporeal exposure of pathogenic peripheral blood leukocytes to the natural compound 8-methoxypsoralen (8-MOP) and ultraviolet A radiation has provided great benefit in certain adv...
A H, Rook   +7 more
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Treatment of Sézary syndrome with extracorporeal photochemotherapy

Transfusion Science, 1994
In the 1980s Edelson et al.’ developed a technique for the extracorporeal irradiation of peripheral blood leucocytes with Smethoxypsoralen and showed that this markedly reduced the viability of irradiated cells. The results of a multicentre trial involving the treatment of 41 patients with cutaneous T-cell lymphoma were published in 1987.
N P, Smith   +6 more
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Severe Pemphigus Foliaceus Treated With Extracorporeal Photochemotherapy

Archives of Dermatology, 1997
REPORT OF A CASE A 64-year-old man presented with a 3-year history of severe pemphigus foliaceus. He had been treated with adequate doses of systemic corticosteroids, azathioprine sodium, intermittent methotrexate sodium, and cyclosporine. Maintenance treatment with prednisone (dose range, 40-60 mg/d) and azathioprine sodium (100 mg/d) was necessary ...
J M, Azaña   +4 more
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Transimmunization and the evolution of extracorporeal photochemotherapy

Transfusion and Apheresis Science, 2002
We are now aware that extracorporeal photopheresis (ECP) - in which a patient's leukocytes are isolated, passed through an ultrathin clear plastic plate, and exposed to 8-methoxypsoralen (8-MOP) and ultraviolet A light prior to reinfusion - is a simple and efficient dendritic cell (DC) therapy and the first FDA approved selective immunotherapy for ...
Michael, Girardi   +4 more
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Treatment of psoriatic arthritis by extracorporeal photochemotherapy

British Journal of Dermatology, 1990
Five patients with long-standing seronegative arthritis resistant to conventional therapy and who also had psoriasis of the skin were treated with photopheresis. This mode of treatment combines a lymphocyte-enrichment procedure with 8-methoxypsoralen-photochemotherapy.
H, Wilfert   +4 more
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Mechanisms of action of extracorporeal photochemotherapy

Transfusion and Apheresis Science, 2003
Extracorporeal photochemotherapy (ECP) has been shown to be effective in variety of pathologic diseases such as Sezary syndrome, autoimmune diseases, organ graft rejection and graft versus host disease. However, its mechanism of action has remained elusive.
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The course of anticoagulation after extracorporeal photochemotherapy

Photodermatology, Photoimmunology & Photomedicine, 2005
During extracorporeal photochemotherapy (ECP) heparin is added to the extracorporeal circulation to avoid clotting. It has not been investigated whether and to what extend this procedure influences coagulation in patients after ECP. In this study activated partial thrombaplastin time (aPTT) and anti‐factor Xa were monitored for up to 4 h after ECP in ...
E, Ivancic   +4 more
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Extracorporeal photochemotherapy for chronic erosive lichen planus

The Lancet, 1998
Topical steroids and retinoic acid are usually ineffective in the treatment of chronic erosive lichen planus (CELP). Improvement with griseofulvin and dapsone has been reported; topical cyclosporin may also help, but only 30% of patients remain improved after 1 year. We noticed that extracorporeal photochemotherapy (ECP) improved the generalised lichen
P A, Bécherel   +5 more
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Treatment of chronic GVHD with extracorporeal photochemotherapy

Transfusion and Apheresis Science, 2013
The results of our center in the use of extracorporeal photopheresis in therapy of chronic GVHD are presented.
Lukić, Marija   +11 more
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