Results 91 to 100 of about 1,460,011 (266)

To Extract, or not to Extract: That is the Question

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2017
Aysenur Ekizler, Serkan Cay, Ozcan Ozeke, Firat Ozcan, Dursun Aras, Serkan Topaloglu   +5 more
openaire   +3 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Antibacterial Effect of Aqueous and Alcoholic Extracts from Petal of Saffron (Crocus sativus L.) on some Foodborne Bacterial Pathogens

Journal of Medicinal Plants, 2012
Background: Health concerns due to adverse effects of chemical preservatives have increased public interest to consuming preservative-free products or product containing natural preservatives such as plant extract and their essential oils.
H Gandomi Nasrabadi, L Azami Sarokelaei, A Misaghi, S Abbaszadeh, N Shariatifar, N Tayyar Hashtjin   +5 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study on Anti_ Candida Effects of Essential Oil and Extracts of Iranian Medicinal Plants, In vitro

Journal of Medicinal Plants, 2011
Background: Candidiasis is a primary or secondary mycotic infection caused by members of the genus Candida. Objective: Recently fungal infections especially Candidiasis has significantly increased.
A Naeini, M Naseri, M Kamalinejad, F Khoshzaban, T Rajabian, H Nami, S Mansori, D Zavieh   +7 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Effects of Pretreatment with Achillea santolina and Stachys athorecalyx Extracts on CFA-induced acute inflammation in male rats

Journal of Medicinal Plants, 2010
Background: Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory
E Tekieh, Sh Rezazadeh, H Manaheji, A Akbari, J Zaringhalam   +4 more
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source