The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pond's Extract the wonder of healers
Trade card advertising Pond's Extract, a remedy prepared by the Pond's Extract Co., New York, N ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Effects of Magnolia denudata extract on quality and storage characteristics of emulsified chicken sausage. [PDF]
Ku B +6 more
europepmc +1 more source
Pond's Extract heals all bruises, wounds, lameness and sprains
Trade card/ink blotter advertising Pond's Extract, a remedy prepared by Pond's Extract Co., New York, N ...
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Comprehensive chemical, morphological, thermal, and biological characterization of Agave tequilana extract and chitosan-based dissolving microneedle arrays. [PDF]
Quintero-Rincón P +2 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Antimicrobial and Nutritional Properties of Edible Oyster Mushroom (<i>Pleurotus ostreatus</i>) Extracts Against Foodborne Pathogens Relevant to Maternal and Child Malnutrition in Africa. [PDF]
Ali AS, Nageye YA, Bello KE.
europepmc +1 more source

