Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Effects of <i>Boswellia serrata</i> on cell viability, scratch wound closure, and gene expression in human gingival fibroblasts. [PDF]
J Oral Biol Craniofac ResGolmohammadi S, Daneshi Z, Anousheh M.
europepmc +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Antifungal and Profungal Potentials of Acetone-Extracted Complexes of Lichen Substances on Macromycete <i>Heterobasidion parviporum</i> Mycelium Growth Dynamics-The First In Vitro Approach. [PDF]
MoleculesFurmanek Ł +7 more
europepmc +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Seasonal metabolomics and antibacterial activity of <i>Abutilon pannosum</i> reveal positive interaction with the lytic phage CF01 against <i>Escherichia coli</i> O157:H7 (strain 161-84). [PDF]
Front MicrobiolAlarjani KM +6 more
europepmc +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Chemical profiling of Egregia menziesii and anti-inflammatory potential in LPS-activated RAW 264.7 macrophages. [PDF]
Mol Biol RepArroyo-Xochihua O +4 more
europepmc +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Physiological effects of foliar-applied β-carotene and carrot root extract on growth, biochemical traits, and yield of two flax varieties grown in sandy soil. [PDF]
BMC Plant BiolYounis AM +4 more
europepmc +1 more source