Formulation of <i>Blumea balsamifera</i>, <i>Anredera cordifolia</i>, and <i>Phyllanthus niruri</i> Extracts as Potential Anti-Inflammatory Agents. [PDF]
Pajriah SM +5 more
europepmc +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Cardioprotective effect of hydroalcoholic extract stem bark of <i>Xeroderris stuhlmannii</i> on cadmium chloride-induced hypertension and its possible vasorelaxant mechanism on isolated aortic rats. [PDF]
Wanche Kojom JJ +5 more
europepmc +1 more source
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Multifunctional effects of Zizyphus mauritiana leaf extract on oral pathogens and wound healing: an integrative in vitro and in vivo study. [PDF]
Poedjiastoeti W +7 more
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
<i>Myrtus communis</i> Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing. [PDF]
Pekmezci E, Türkoğlu M.
europepmc +1 more source
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Phytochemical directed synthesis of flower-like ZnO nanostructures from almond peel extract for sunlight-activated congo red degradation. [PDF]
Sudarsan S +3 more
europepmc +1 more source

