Results 41 to 50 of about 390,157 (287)

Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring.

PLoS ONE, 2015
We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and glucose from skin in vitro and in vivo.
Ester Caffarel-Salvador, Aaron J Brady, Eyman Eltayib, Teng Meng, Ana Alonso-Vicente, Patricia Gonzalez-Vazquez, Barbara M Torrisi, Eva Maria Vicente-Perez, Karen Mooney, David S Jones, Steven E J Bell, Colin P McCoy, Helen O McCarthy, James C McElnay, Ryan F Donnelly   +14 more
doaj   +1 more source

New Operative Protocol for Immediate Post-Extraction Implant in Lower-First-Molar Region with Rex-Blade Implants: A Case Series with 18 Months of Follow-Up

Applied Sciences, 2023
In this manuscript, the authors propose a new technique for inserting implants immediately into the sockets corresponding to the lower first molars and, in any case, in the sockets in which the alveolar septum is still present.
Fabrizio Bambini, Lucia Memè, Roberto Rossi, Andrea Grassi, Serena Grego, Stefano Mummolo   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Isolation of a transcriptionally active element of high copy number retrotransposons in sweetpotato genome [PDF]

, 2004
Many plant retrotransposons have been characterized, but only three families (Tnt1, Tto1 and Tos17) have been demonstrated to be transpositionally competent.
Aoki, Takahiro, Kokumai, Shuhei, Matsunaga, Sachi, Suzuka, Shinya, Tahara, Makoto, Tanaka, Masaru, Yamashita, Hiroki   +6 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Multiple determinants direct the orientation of signal-anchor proteins : the topogenic role of the hydrophobic signal domain [PDF]

, 1997
The orientation of signal-anchor proteins in the endoplasmic reticulum membrane is largely determined by the charged residues flanking the apolar, membrane-spanning domain and is influenced by the folding properties of the NH2-terminal sequence. However,
Andrews, Beltzer, Cullen, Dalbey, Denzer, Ellis, Gilmore, Hartmann, Kyte, Monier, Munro, Nilsson, Parks, Parks, Parks, Sakaguchi, Sato, Schmid, Spiess, Spiess, Spiess, Spiess, Szczesna-Skorupa, Szczesna-Skorupa, Voigt, von Heijne, von Heijne, von Heijne, von Heijne, von Heijne, Wahlberg, Walter   +31 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

D-Tree Grammars

, 1995
DTG are designed to share some of the advantages of TAG while overcoming some of its limitations. DTG involve two composition operations called subsertion and sister-adjunction.
Rambow, Owen, Vijay-Shanker, K., Weir, David   +2 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Stabilization of oxygen vacancy ordering and electrochemical-proton-insertion-and-extraction-induced large resistance modulation in strontium iron cobalt oxides Sr(Fe,Co)O y

Nature Communications
Electrochemically inserting and extracting hydrogen into and from solids are promising ways to explore materials’ phases and properties. However, it is still challenging to identify the structural factors that promote hydrogen insertion and extraction ...
Yosuke Isoda, Thanh Ngoc Pham, Ryotaro Aso, Shuri Nakamizo, Takuya Majima, Saburo Hosokawa, Kiyofumi Nitta, Yoshitada Morikawa, Yuichi Shimakawa, Daisuke Kan   +9 more
doaj   +1 more source