Results 171 to 180 of about 3,634,641 (304)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Patent-extracted chemistry in PubChem

Updates July 2025 Minor changes but good news in that SureChEMBL 2.0  (bless 'em) now  appears to be updating in PubChem more often and just broke 30 million :) In turn, this brings the total CNER submissions up to 47.7 million and, more importantly, the corroborative intersect between the big three active ...
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

In vitro antimicrobial potential and phytochemical analysis of root extracts of Rumex abyssinicus from southern Ethiopia. [PDF]

PLoS One
Ameya G, Manilal A, Abdulkadir M, Gelana T, Sabu KR.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Magnetic montmorillonite functionalized with UiO-66 metal-organic framework as a hierarchical adsorbent for magnetic solid-phase extraction of polycyclic aromatic hydrocarbons. [PDF]

RSC Adv
Hosseininia M, Amiri A, Mirzaei M.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Machine learning-assisted green extraction of polysaccharides from Syringa oblata Lindl leaf residue using natural deep eutectic solvents: process optimization, structural characterization, and bioactivities. [PDF]

Ultrason Sonochem
Jiang S, Zhang S, Han J, Feng Z, Xu Y, Shen Y, Zhong Y, Huang X, Gao R, Yu X, Wang Q, Wu X, Wei L, Jiang M, Wang Z, Wang X, Gan C, Yang C.   +17 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Schiff Base-UiO66 Composite-based Dispersive Micro Solid-Phase Extraction of Pesticides From Fruit Juices Combined With Dispersive Liquid-Liquid Microextraction Prior to Gas Chromatography-Flame Ionisation Detection. [PDF]

Anal Sci Adv
Hosseininezhad B, Bomorovat M, Nemati M, Farajzadeh MA, Atazadeh R, Afshar Mogaddam MR.   +5 more
europepmc   +1 more source