Results 51 to 60 of about 407,586 (267)

Experimental investigation on the carob extraction using arrhenius approach and response surface

Scientific Reports
Environmental problems have increased the need for sustainable agricultural practices that conserve water and energy. Carob, an eco-friendly crop with multiple health benefits, holds the potential for economic evaluation.
Mehmet Berkant Özel, Ufuk Durmaz, Mustafa Özdemir, Orhan Yalçınkaya, Norah Salem Alsaiari, Sultan Alomairy, M. S. Al-Buriahi   +6 more
doaj   +1 more source

Extraction of glycyrrhizic acid by aqueous two-phase system formed by PEG and two environmentally friendly organic acid salts - sodium citrate and sodium tartrate

Green Processing and Synthesis, 2019
Two aqueous two-phase systems (ATPS’s) formed by using PEG and sodium citrate/sodium tartrate are applied and compared for extraction of glycyrrhizic acid (GA) from its stock solution. Their binodal curves and tie-lines are studied firstly.
Zhang Zhi Feng, Wang Rui, Ye Fei, Wang Haibin, Zhao Wenxia   +4 more
doaj   +1 more source

Malic acid extraction from aqueous solution by using aqueous two-phase system method

Results in Chemistry, 2019
In this investigation malic acid extraction by aqueous two-phase system method (ATPS) was performed. ATPS are involved polymer (PEG 4000 and 8000) and various phosphate salts. Effect of PEG molecular weight, pH, temperature and concentration of salt were
Hadiseh Masoumi, Hamid Ramezanipour Penchah, Hossein Ghanadzadeh Gilani, Tahereh Jangjooye Shaldehi   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Comparative Experimental Investigation for the Separation of Tartaric Acid by Natural and Conventional Solvents

Journal of Applied Science & Process Engineering
Tartaric acid (TA), a valuable organic acid with widespread applications in food, pharmaceutical, and chemical industries, is predominantly found in grapes and winery by-products.
Aryawardhan.Y. Solanki, Ashwini Thakre, Diwakar Shende, Kailas Wasewar   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A novel extraction model optimization with effective separation coefficient for rare earth extraction process using improve differential evolution

Scientific Reports
The mechanistic model of the rare earth extraction process neglects the efficacy of the agitator within the extraction extractor. This oversight results in a significant discrepancy between the theoretical solute concentration at each stage and the ...
Fangping Xu, Hui Yang, Jianyong Zhu, Wenjia Chang   +3 more
doaj   +1 more source