Results 201 to 210 of about 81,110 (304)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Enhanced detoxification and valuable metal extraction from electroplating sludge via ultrasonic-assisted ferric sulfate bio acid. [PDF]

Sci Rep
Kordloo M, Jafari N, Rezaei A, Noeparast H, Nasab MH, Ghorbani Y.   +5 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Genome-wide screening reveals producer-cell modifications that improve virus-like particle production and delivery potency. [PDF]

Nat Commun
Ly D, Jang H, Goel A, Singh A, Raguram A.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Process and Kinetics of V and W Leaching from Spent SCR Catalysts via Pressure Alkali Leaching. [PDF]

ACS Omega
Shuting W, Xueyong W, Tingtao B, Zixuan Y, Xuekui N, Mina W, Wei W, Tao Z.   +7 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Polyphenol-Driven Interfacial Control: How <i>Achillea millefolium</i> Extract Modulates Mild Carbon Steel Corrosion in Acid and Neutral Media. [PDF]

Materials (Basel)
Badea GE, Maior I, Petrehele AIG, Stănășel OD, Fodor A, Sebeșan M, Dzitac S, Ionaș CD.   +7 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole-tetrahydroxamic acid receptor. [PDF]

Beilstein J Org Chem
Karnib S, Baydoun R, Zaidan W, AlHaddad N, El Samad O, Nsouli B, Cazier-Dennin F, Danjou PE.   +7 more
europepmc   +1 more source