Results 41 to 50 of about 1,492 (259)

Water-soluble phenolic compounds produced from extractive ammonia pretreatment exerted binary inhibitory effects on yeast fermentation using synthetic hydrolysate. [PDF]

PLoS ONE, 2018
Biochemical conversion of lignocellulosic biomass to liquid fuels requires pretreatment and enzymatic hydrolysis of the biomass to produce fermentable sugars. Degradation products produced during thermochemical pretreatment, however, inhibit the microbes
Saisi Xue, A Daniel Jones, Leonardo Sousa, Jeff Piotrowski, Mingjie Jin, Cory Sarks, Bruce E Dale, Venkatesh Balan   +7 more
doaj   +1 more source

Increased Water-Soluble Yellow Monascus Pigment Productivity via Dual Mutagenesis and Submerged Repeated-Batch Fermentation of Monascus purpureus

Frontiers in Microbiology, 2022
Monascus pigments (MPs) have been used in the food industry for more than 2,000 years and are known for their safety, bold coloring, and physiological activity. MPs are mainly yellow (YMPs), orange (OMPs), and red (RMPs).
Jie Bai, Zihan Gong, Meng Shu, Hui Zhao, Fanyu Ye, Chenglun Tang, Chenglun Tang, Song Zhang, Bo Zhou, Dong Lu, Xiang Zhou, Qinlu Lin, Jun Liu, Jun Liu   +13 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Extractive Ethanol Fermentation with Ethanol Recovery by Absorption in Open and Closed Systems

Fermentation
Conventional ethanol production has limitations, including substrate and product inhibitions, which increase both energy requirements for ethanol recovery and vinasse generation. Extractive fermentation, which removes ethanol as it is produced within the
Kaio César da Silva Rodrigues, Ivan Ilich Kerbauy Veloso, Diego Andrade Lemos, Antonio José Gonçalves Cruz, Alberto Colli Badino   +4 more
doaj   +1 more source

Extractive adsorption of 1,3-propanediol on a novel polystyrene macroporous resin enclosing medium and long-chain alcohols as extractant

Bioresources and Bioprocessing, 2023
Extractive adsorption is an integrated separation method employing a novel resin with both particle and liquid characteristics in terms of adsorption and extraction.
Wen-Bo Sui, Lu-Sheng Huang, Xiao-Li Wang, Xu Zhou, Ya-Qin Sun, Zhi-Long Xiu   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Process simulation and optimization of extractive distillation for separating isopropanol-ethanol from IBE fermentation broth as a gasoline additive

Industrial Crops and Products
Addressing the downstream processing challenges of the bio-butanol fermentation broth (Isopropanol-Butanol-Ethanol-Water), and producing the isopropanol-ethanol mixture with a mass fraction of ≥ 0.99975 as a high-quality gasoline additive, is crucial for
Xiuhui Huang, Yi Jin, Chenhao Fang, Wenkai Yang, Zeqiu Li, Ying Tian   +5 more
doaj   +1 more source

In Situ Product Recovery of Bio-Based Industrial Platform Chemicals: A Guideline to Solvent Selection

Fermentation, 2021
In situ product recovery (ISPR), in the form of an extractive fermentation process, can increase productivity and product titers in the sustainable production of platform chemicals.
Pieter De Brabander, Evelien Uitterhaegen, Ellen Verhoeven, Cedric Vander Cruyssen, Karel De Winter, Wim Soetaert   +5 more
doaj   +1 more source