Results 81 to 90 of about 35,575 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Combination of Analytical Pyrolysis and fractionation of technical lignin as a tool for improvement of its antioxidant properties [PDF]

open access: yes, 2012
Antioxidant properties of parent lignin and its fractions was assessed in the tests with free radicals ABTS•+ and DPPH. Increasing ratio between content of syringyl and guaiacyl substructures and the extent of conjugation of lignin macromolecule (Py-GC ...
Arshanitsa, Alexandr   +4 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Wood resistance of Magonia pubescens (Sapindaceae), Dalbergia nigra, and Machaerium amplum (Fabaceae) to Nasutitermes sp. (Blattodea: Termitidae) [PDF]

open access: yesBrazilian Journal of Biology
Termites of the genus Nasutitermes sp. (Blattodea: Termitidae), which feed on cellulose, may cause wood to become brittle and fragile. This study aimed to evaluate the natural resistance of three native wood species: Magonia pubescens (Sapindaceae ...
S. A. G. Souza   +9 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Investigation of the Amount of Tannic Acid in Bark Oak (Quercus castanifolia) [PDF]

open access: yesIranian Journal of Wood and Paper Industries, 2011
In order to perform a qualitative and quantitative investigation on tannic acid content in Oak bark, the bark samples were collected from Educational Forest of Gorgan Agricatural Science and Natural Resources University.
Shayesteh Jahanshahi   +3 more
doaj  

Comparative Research on the Structure, Chemistry, and Physical Properties of Turkey Oak and Sessile Oak Wood

open access: yesBioResources, 2023
The objective of this research was to establish comparatively some relevant features of Turkey oak and sessile oak wood, in order to better understand the drying behavior of these species.
Iulia Deaconu   +4 more
doaj  

Swelling of acetylated wood in organic liquids

open access: yes, 2005
To investigate the affinity of acetylated wood for organic liquids, Yezo spruce wood specimens were acetylated with acetic anhydride, and their swelling in various liquids were compared to those of untreated specimens. The acetylated wood was rapidly and
A. N. NAYER   +10 more
core   +2 more sources

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