Results 91 to 100 of about 13,474 (184)

Capture of Totipotency in Mouse Embryonic Stem Cells in the Absence of Pdzk1

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This work provides a new strategy to capture totipotency in ESCs by deletion of Pdzk1. Pdzk1‐null ESCs can integrate to fetus, placenta, and yolk sac tissues easily in chimera experiment, and also can self‐organize to form blastocyst‐like structures efficiently. The developmental potentials of Pdzk1‐KO ESCs are mainly through up‐regulating some lineage
Wenhao Zhang, Yiding Zhao, Zhe Yang, Jing Yan, Haisong Wang, Shaochen Nie, Qingshen Jia, Dan Ding, Chao Tong, Xiao‐Ou Zhang, Qian Gao, Ling Shuai   +11 more
wiley   +1 more source

Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig

Reproduction and Fertility
The eutherian placenta is highly complex, evolving to regulate the inflammatory phase of pregnancy during conceptus attachment and placental tissue development. Tripartite motif family-like (TRIMLs) proteins are implicated in downregulating inflammation.
Emily K Eitel, Mariana Sponchiado, Riley M Sullivan, Caroline G Lucas, Bethany K Redel, Paula R Chen, Kevin D Wells, Randall S Prather, Wesley C Warren, Rodney D Geisert   +9 more
doaj   +1 more source

Spatial Dynamic Structures and Mobility in Computation [PDF]

arXiv, 2011
Membrane computing is a well-established and successful research field which belongs to the more general area of molecular computing. Membrane computing aims at defining parallel and non-deterministic computing models, called membrane systems or P Systems, which abstract from the functioning and structure of the cell.
arxiv  

Membrane morphologies induced by arc-shaped scaffolds are determined by arc angle and coverage [PDF]

, 2019
The intricate shapes of biological membranes such as tubules and membrane stacks are induced by proteins. In this article, we systematically investigate the membrane shapes induced by arc-shaped scaffolds such as proteins and protein complexes with coarse-grained modeling and simulations.
arxiv   +1 more source

WDR36 Regulates Trophectoderm Differentiation During Human Preimplantation Embryonic Development Through Glycolytic Metabolism

Advanced Science, Volume 12, Issue 5, February 3, 2025.
WD repeat domain 36 (WDR36) is essential for early embryonic development. Using a human 8CLC‐derived blastoid model, this study demonstrates that inhibiting WDR36 disrupts trophectoderm commitment. Transcriptomic and metabolomic analyses reveal a downregulation of glucose metabolism in WDR36 interfered‐blastoid, linking WDR36 to glycolysis and cell ...
Shiyu An, Shuyue Hou, Feifei Xu, Huanyu Yan, Wenyi Zhang, Jinfeng Xiang, Haoran Chen, Hanwen Zhang, Lingling Dong, Xiaobin Sun, Ran Huo, Yun Chen, Xi Wang, Yang Yang   +13 more
wiley   +1 more source

Metric dynamics for membrane transformation through regulated cell proliferation [PDF]

arXiv, 2016
This study develops an equation for describing three-dimensional membrane transformation through proliferation of its component cells regulated by morphogen density distributions on the membrane. The equation is developed in a two-dimensional coordinate system mapped on the membrane, referred to as the membrane coordinates.
arxiv  

Membrane-mediated interactions [PDF]

, 2019
Interactions mediated by the cell membrane between inclusions, such as membrane proteins or antimicrobial peptides, play important roles in their biological activity. They also constitute a fascinating challenge for physicists, since they test the boundaries of our understanding of self-assembled lipid membranes, which are remarkable examples of two ...
arxiv   +1 more source

Evaluation of chicken chorioallantoic membrane model for tumor imaging and drug development: Promising findings

Animal Models and Experimental Medicine, Volume 8, Issue 2, Page 287-294, February 2025.
Schematic design of this study. The SPF grade fertilized eggs were incubated in a constant temperature incubator for 3 days and the windows were opened. The tumor cells were then inoculated in CAM on Day 10 of incubation. The radioactive molecular probe was injected intravenously and micro PET imaging was performed on Day 18 of incubation.
Lizhen Wang, Junjie Yan, XinyuWang, Yuping Xu, Donghui Pan, Chongyang Chen, Ying Shao, Xiangjun Song, Kezong Qi, Min Yang, Jian Tu   +10 more
wiley   +1 more source

Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology

Developmental Dynamics, Volume 254, Issue 2, Page 102-141, February 2025.
Abstract The ventral body wall (VBW) that encloses the thoracic and abdominal cavities arises by extensive cell movements and morphogenetic changes during embryonic development. These morphogenetic processes include embryonic folding generating the primary body wall; the initial ventral cover of the embryo, followed by directed mesodermal cell ...
Caroline Formstone, Bashar Aldeiri, Mark Davenport, Philippa Francis‐West   +3 more
wiley   +1 more source

Extraembryonic mesoderm cells derived from human embryonic stem cells rely on Wnt pathway activation

Cell Proliferation, Volume 58, Issue 2, February 2025.
Human primed embryonic stem cells drived EXMCs by activating the Wnt pathway showed EXMC characteristics and the sorted EXMCs were able to generate significant quantities of ECM proteins and E‐MSCs in the process of chondrogenesis and osteogenesis. Abstract Extraembryonic mesoderm cells (EXMCs) are involved in the development of multiple embryonic ...
Si‐Le Wang, Gao‐Hui Shi, Kui Duan, Yu Yin, Tianqing Li   +4 more
wiley   +1 more source