Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud [PDF]
, 1995 Mice homozygous for the recessive limb deformity (ld) mutation display both limb and renal defects. The limb defects, oligodactyly and syndactyly, have been traced to improper differentiation of the apical ectodermal ridge (AER) and shortening of the ...
Chan, David C. +2 more
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Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model [PDF]
, 2008 A polyglutamine expansion in the huntingtin (HTT) gene causes neurodegeneration in Huntington’s disease (HD), but the in vivo function of the native protein (Htt) is largely unknown. Numerous biochemical and in vitro studies have suggested a role for Htt
Feany, Mel B. +4 more
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Cell death and morphogenesis during early mouse development: Are they interconnected? [PDF]
, 2015 Shortly after implantation the embryonic lineage transforms from a coherent ball of cells into polarized cup shaped epithelium. Recently we elucidated a previously unknown apoptosis‐independent morphogenic event that reorganizes the pluripotent lineage ...
Bedzhov, Ivan, Zernicka-Goetz, Magdalena
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Function of Bmpr1a in ES cell differentiation and cell competition [PDF]
, 2010 Bone morphogenetic protein (BMP) 4 signalling via BMPR1A is required for the maintenance of the epiblast in the early embryo, and for self-renewal of pluripotent mouse embryonic stem (ES) cells by inhibiting neural differentiation.
Sancho, Maria Margarida Gouveia +1 more
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Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
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The transcription factor GATA6 is essential for early extraembryonic development [PDF]
, 1999 The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a beta-galactosidase marker gene. The analysis of heterozygote GATA6/lacZ mice shows two inductions of GATA6 expression early in ...
Beddington, R. +4 more
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Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo [PDF]
, 2014 A critical point in mammalian development is when the early embryo implants into its mother's uterus. This event has historically been difficult to study due to the fact that it occurs within the maternal tissue and therefore is hidden from view. In this
Bedzhov, Ivan +3 more
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The FASEB Journal, 2010 Oviparous reptile embryos receive a significant proportion of their calcium from the eggshell. For chickens, ≥ 80% of hatchling calcium originates from the shell while for oviparous snakes the shell accounts for 20–25% of hatchling calcium. The chick chorioallantois, which lies just beneath the eggshell, expresses carbonic anhydrase II (CAII) late in ...
James R. Stewart +3 more
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, 2015 Discarded at birth, the placenta is a highly complex and fascinating organ. During the course of a pregnancy, it acts as the lungs, gut, kidneys, and liver of the fetus.
Burton, Graham J, Jauniaux, Eric
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Current status of in vitro differentiation of stem cells into gametes [PDF]
, 2015 From an evolutionary point of view, the gametes are the cells in the body that matter the most as they are the ones who transmit their genes to the next generation ensuring continuation of the species. Being able to generate mature oocytes in vitro is of
Chuva de Sousa Lopes, Susana Marina +1 more
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