Evolving Lessons on Metazoan Primordial Germ Cells in Diversity and Development
Molecular Reproduction and Development, Volume 92, Issue 5, May 2025.ABSTRACT Germ cells are pivotal for the continuation of biological species. The metazoan germline develops from primordial germ cells (PGCs) that undergo multiple rounds of mitotic divisions. The PGCs are specified by either maternal inheritance of asymmetrically polarized cytoplasmic mRNAs/proteins (found in roundworms, flies, fishes, frogs, and fowl)
Indrashis Bhattacharya +5 more
wiley +1 more source
Anterior Visceral Endoderm Directs Ventral Morphogenesis and Placement of Head and Heart via BMP2 Expression [PDF]
, 2011 SummaryIn amniotes, ventral folding morphogenesis achieves gut internalization, linear heart tube formation, ventral body wall closure, and encasement of the fetus in extraembryonic membranes.
Lacy, Elizabeth, Madabhushi, Mary
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Maternal IgE Influence on Fetal and Infant Health
Immunological Reviews, Volume 331, Issue 1, May 2025.ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla +2 more
wiley +1 more source
Ultrastructural analysis of lipid incorporation in the embryonic silkworm, Bombyx mori. [PDF]
, 2009 Insect eggs store many lipid droplets as an energy source for embryonic development. We previously reported that lipid droplets are incorporated into embryos in three steps in the silkworm, Bombyx mori.
5345 +9 more
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American Journal of Reproductive Immunology, Volume 93, Issue 4, April 2025.ABSTRACT Stillbirth affects approximately 2 million pregnancies annually and is closely linked to placental dysfunction, which may also present clinically as foetal growth restriction (FGR) or pre‐eclampsia (PE). Placental dysfunction can arise from a range of insults, including the inflammatory conditions villitis of unknown aetiology (VUE) and ...
Chloe G. Moss +4 more
wiley +1 more source
Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity [PDF]
, 1995 Strong's Luxoid (1st^D) is a semidominant mouse mutation in which heterozygotes show preaxial hindlimb polydactyly, and homozygotes show fore- and hindlimb polydactyly.
Chan, David C. +3 more
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The placenta: a multifaceted, transient organ. [PDF]
, 2015 The placenta is arguably the most important organ of the body, but paradoxically the most poorly understood. During its transient existence, it performs actions that are later taken on by diverse separate organs, including the lungs, liver, gut, kidneys ...
Burton, Graham J, Fowden, Abigail L
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Pre-implantation maternal uterine effects on embryo growth and development : an investigation using models of maternal constraint in sheep : a thesis presented in fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science, Massey University, Turitea, Palmerston North, New Zealand [PDF]
, 2017 Listed in 2017 Dean's List of Exceptional ThesesPrenatal development and growth are critical to survival of the fetus and neonate. Recent evidence suggests that a critical period for determining growth is the pre-implantation period of pregnancy during
Fermin, Lisanne Monique
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Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development [PDF]
, 2012 International audienceThe transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors
Azuara, Veronique +12 more
core +2 more sources
Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. [PDF]
, 2016 Mammalian Host-Cell Factor 1 (HCF-1), a transcriptional co-regulator, plays important roles during the cell-division cycle in cell culture, embryogenesis as well as adult tissue. In mice, HCF-1 is encoded by the X-chromosome-linked Hcfc1 gene.
Bessonnard, S. +5 more
core +1 more source