Results 51 to 60 of about 143,234 (261)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
On some extensions of the accelerated overrelaxation (AOR) theory
International Journal of Mathematics and Mathematical Sciences, 1982 This paper extends the convergence theory of the Accelerated Overrelaxation (AOR) method to cases analogous to those considered first by Ostrowski and then by Varga in connection with the Successive Overrelaxation (SOR) method.
A. Hadjidimos, A. Yeyios
doaj +1 more source
Extrapolation Merging: Keep Improving With Extrapolation and Merging
CoRRLarge Language Models (LLMs) require instruction fine-tuning to perform different downstream tasks. However, the instruction fine-tuning phase still demands significant computational resources and labeled data, lacking a paradigm that can improve model performance without additional computational power and data.
Yiguan Lin +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Abstract Weighted Morrey Spaces and Applications
AxiomsWe introduce the abstract weighted Morrey spaces Mp,uκ(X,M,μ), where μ is a general measure; investigate the properties of their predual spaces; and prove the boundedness of the Hardy–Littlewood maximal operator.
Yuchen Li, Jiang Zhou
doaj +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
THE VICISSITUDES OF THE HUMANITIES
Образование и наука, 2016 The aims of the article: – to track the change of approaches to humanitarian knowledge; – to define possible ways of its development at the present stage.Methods. The methodology of the research is based on the content analysis of verbal and visual texts,
N. N. Belozerova
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Probabilistic Richardson extrapolation
Journal of the Royal Statistical Society Series B: Statistical MethodologyAbstract For over a century, extrapolation methods have provided a powerful tool to improve the convergence order of a numerical method. However, these tools are not well-suited to modern computer codes, where multiple continua are discretized and convergence orders are not easily analysed.
Chris J. Oates +4 more
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
A Symmetry-Preserving Extrapolated Primal-Dual Hybrid Gradient Method for Saddle-Point Problems
AxiomsThe primal-dual hybrid gradient (PDHG) method is widely used for convex–concave saddle-point problems, yet its extrapolated variants are typically asymmetric because only one side is extrapolated.
Xiayang Zhang +4 more
doaj +1 more source