Results 91 to 100 of about 3,281 (261)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Extremum statistics: a framework for data analysis [PDF]

Nonlinear Processes in Geophysics, 2002
Recent work has suggested that in highly correlated systems, such as sandpiles, turbulent fluids, ignited trees in forest fires and magnetization in a ferromagnet close to a critical point, the probability distribution of a global quantity (i.e ...
S. C. Chapman, G. Rowlands, N. W. Watkins   +2 more
doaj  

Scalar Dyon Production In Near Extremal Kerr-Newman Black Holes

EPJ Web of Conferences, 2018
The pair production of charged scalar dyons is analytically studied in near-extremal Kerr-Newman (KN) dyonic black holes. The pair production rate and its thermal interpretation are given.
Chen Chiang-Mei, Kim Sang Pyo, Sun Jia-Rui, Tang Fu-Yi   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Extremal functions for Bloch constants [PDF]

Kodai Mathematical Journal, 1988
The author establishes an intriguing inequality for a function f that is holomorphic in the open unit disk \({\mathbb{D}}\) and extremal for any one of the following: the Bloch, Landau, locally schlicht Bloch or univalent Bloch constant. If f is such an extremal function, then \[ | \lim_{\epsilon \to 0}\frac{1}{\pi}\int_{\epsilon
openaire   +2 more sources

One-loop determinant in the extremal black hole from quasinormal modes

Journal of High Energy Physics
In this paper, we evaluate the one-loop partition function of a scalar field in the near-horizon geometry of the extremal Reissner Nordström black hole from an infinite product over quasinormal modes using the Denef-Hartnoll-Sachdev (DHS) formula.
Jyotirmoy Mukherjee
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Scalar tidal response of a rotating BTZ black hole

Journal of High Energy Physics
We study the response of a rotating BTZ black hole to the scalar tidal perturbation. We show that the real component of the tidal response function isn’t zero, indicating that a rotating BTZ black hole possesses non-zero tidal Love numbers. Additionally,
Rajendra Prasad Bhatt, Chiranjeeb Singha
doaj   +1 more source