Results 101 to 110 of about 3,281 (261)
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Univalent functions maximizing Re[f(ζ1)+f(ζ2)]
International Journal of Mathematics and Mathematical Sciences, 1996 We study the problem maxh∈Sℜ[h(z1)+h(z2)] with z1,z2 in Δ. We show that no rotation of the Koebe function is a solution for this problem except possibly its real rotation, and only when z1=z¯2 or z1,z2 are both real, and are in a neighborhood of the x ...
Intisar Qumsiyeh Hibschweiler
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
The extremal function for \(K_{8}^{-}\) minors
Journal of Combinatorial Theory, Series B, 2005 A result of Mader from 1968, which was instrumental for the proof of the special case of Hadwiger's conjecture by Robertson, Seymour and Thomas for graphs without \(K_6\) minor, states that for \(p\leq 7\) every graph \(G\) with sufficiently many edges has a \(K_p\) minor.
openaire +2 more sources
Oszacowanie parametrów liniowych okrętu w pewnym zbiorze obciążeń
Engineering Transactions, 1966 Estimation of the linear parameters of a ship in some a set loads The object of the considerations is the problem of integral extrema of the functional (2.1) in the set (2.3) of continuous functions having sectionally continuous derivatives.
Jan WIĘCKOWSKI
doaj
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli +5 more
wiley +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
The Hörmander--Bernhardsson extremal function
Some typos corrected.
Bondarenko, Andriy +3 more
openaire +3 more sources