Results 41 to 50 of about 34,690 (269)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Maximal tree and unicylic graph for Euler Sombor index with given diameter

AKCE International Journal of Graphs and Combinatorics
The study of topological descriptors is essential for understanding the underlying structures of graphs and networks. Numerous numerical descriptors associated with graphs have been used to analyze their overall structure.
Zahid Raza, Shehnaz Akhter, Sourav Mondal, Modjtaba Ghorbani   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Extremal Topological Indices with Prescribed Degree Sequences

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
This paper explores the extremal properties and bounds of two significant topological indices in graph theory: the Albertson and Sigma indices, with an emphasis on trees and bipartite graphs.
Hamoud, J., Belov, A.Ya.
doaj   +1 more source

Choosing Wavelet Methods, Filters, and Lengths for Functional Brain Network Construction. [PDF]

PLoS ONE, 2016
Wavelet methods are widely used to decompose fMRI, EEG, or MEG signals into time series representing neurophysiological activity in fixed frequency bands.
Zitong Zhang, Qawi K Telesford, Chad Giusti, Kelvin O Lim, Danielle S Bassett   +4 more
doaj   +1 more source

On singular probability densities generated by extremal dynamics

, 2004
Extremal dynamics is the mechanism that drives the Bak-Sneppen model into a (self-organized) critical state, marked by a singular stationary probability density $p(x)$.
Bak, Boettcher, Bose, Caldarelli, Dickman, Dickman, Donangelo, Dorogovtsev, Drossel, Felici, Grassberger, Guilherme J.M. Garcia, Head, Head, Li, Marsili, Maslov, Meester, Mikeska, Paczuski, Paczuski, Pismak, Rios, Ronald Dickman   +23 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

On the KG-Sombor index

Vojnotehnički Glasnik
Introduction/purpose: Degree-based graph invariants are a type of molecular descriptor that represent the connectivity of atoms (vertices) in a molecule through bonds (edges). They are used to model structural properties of molecules and provide valuable
Ochirbat Altangoo, Dechinpuntsag Bolormaa, Badarch Gantuya, Tsend-Ayush Selenge   +3 more
doaj   +1 more source

The Lagrangian Density of {123, 234, 456} and the Turán Number of its Extension

Discussiones Mathematicae Graph Theory, 2021
Given a positive integer n and an r-uniform hypergraph F, the Turán number ex(n, F ) is the maximum number of edges in an F -free r-uniform hypergraph on n vertices.
Chen Pingge, Liang Jinhua, Peng Yuejian
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source