Results 61 to 70 of about 1,552,101 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conditional simulation of max-stable processes

, 2012
Since many environmental processes such as heat waves or precipitation are spatial in extent, it is likely that a single extreme event affects several locations and the areal modelling of extremes is therefore essential if the spatial dependence of ...
Dombry, Clément, Ribatet, Mathieu, Éyi-Minko, Frédéric   +2 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Regional Variations in Drivers of Extreme Reference Evapotranspiration Across the Contiguous United States

Water Resources Research
Extremely high reference evapotranspiration indicates an abnormal atmospheric water demand, with significant implications for regional water resource management.
Bingjie Zhao, Christopher Horvat, Christopher Pearson, Deep Shah, Huilin Gao   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Extreme Magnification Microlensing Event OGLE-2008-BLG-279: Strong Limits on Planetary Companions to the Lens Star [PDF]

, 2009
We analyze the extreme high-magnification microlensing event OGLE-2008-BLG-279, which peaked at a maximum magnification of A ~ 1600 on 30 May 2008.
A. Cassan, A. Cole, A. Fukui, A. Gould, A. Maury, A. Shporer, A. Udalski, A. V. Korpela, A. Williams, B. -G. Park, B. S. Gaudi, Batista, Bennett, Bond, C. -U. Lee, C. Coutures, C. H. Ling, C. Han, Claret, Cox, D. Higgins, D. J. Sullivan, D. Kubas, D. L. DePoy, D. Maoz, D. P. Bennett, D. Polishook, Demarque, Dong, Dong, F. Abe, F. Mallia, G. Pietrzyński, G. W. Christie, Gaudi, Gaudi, Gaudi, Gould, Gould, Gould, Griest, Hardy, Holz, I. A. Bond, I. Soszyński, Ida, Ida, J. -P. Beaulieu, J. B. Hearnshaw, J. C. Bird, J. C. Yee, J. Comparat, J. D. Eastman, J. Greenhill, J. McCormick, J. Menzies, J. Wambsganss, Janczak, K. Furusawa, K. Horne, K. Kamiya, K. Masuda, K. Nishimoto, K. Ohnishi, K. Ulaczyk, L. A. G. Monard, L. Skuljan, Laughlin, M. Bos, M. D. Albrow, M. K. Szymański, M. Kubiak, M. Nagaya, M. Zub, N. J. Rattenbury, N. Kains, N. Miyake, O. Spector, O. Szewczyk, P. C. M. Yock, P. Fouqué, P. J. Tristram, P. M. Kilmartin, Poindexter, R. Martin, R. Poleski, R. Santallo, R. W. Pogge, Rhie, S. Dieters, S. Hosaka, S. Kaspi, S. Kozłowski, S. Makita, Subo Dong, T. Natusch, T. Sako, T. Sumi, To. Saito, Udalski, V. Batista, W. Allen, W. L. Sweatman, W. Lin, Wozniak, Y. C. Perrott, Y. Itow, Y. Matsubara, Y. Muraki, Yee, Yoo, Ł. Wyrzykowski   +111 more
core   +7 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Motivations for local climate adaptation in Dutch municipalities: climate change impacts and the role of local-level government [PDF]

, 2009
The local government level is considered to be crucial in preparing society for climate change impact. Yet little is known about why local authorities do or do not take action to adapt their community for climate change impacts.
Berg, Maya M. van den
core   +1 more source

Perturbative Analysis of a Stationary Magnetosphere in an Extreme Black Hole Spacetime : On the Meissner-like Effect of an Extreme Black Hole

, 2010
It is known that the Meissner-like effect is seen in a magnetosphere without an electric current in black hole spacetime: no non-monopole component of magnetic flux penetrates the event horizon if the black hole is extreme. In this paper, in order to see
Bic̆ák, Bic̆ák, Bic̆ák, Blandford, Chul-Moon Yoo, Contopoulos, Gruzinov, Hawley, Hideki Ishihara, Ken-ichi Nakao, Komissarov, Komissarov, MacDonald, Masashi Kimura, McKinney, McKinney, Nagataki, Ogura, Tanabe, Tchekhovsky, Timokhin, Uzdensky, Uzdensky, Yohsuke Takamori, Znajek   +24 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source