Results 61 to 70 of about 3,017,157 (340)

The extremal point process of branching Brownian motion in $\mathbb{R}^d$ [PDF]

, 2021
Julien Berestycki, Yujin H. Kim, Eyal Lubetzky, Bastien Mallein, Ofer Zeitouni   +4 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiobjective Personalized Recommendation Algorithm Using Extreme Point Guided Evolutionary Computation

Complexity, 2018
Recommender systems suggest items to users based on their potential interests, and they are important to alleviate the search and selection pressures induced by the increasing item information.
Qiuzhen Lin, Xiaozhou Wang, Bishan Hu, Lijia Ma, Fei Chen, Jianqiang Li, Carlos A. Coello Coello   +6 more
doaj   +1 more source

Extreme purifying selection against point mutations in the human genome [PDF]

, 2021
Noah Dukler, Mehreen R. Mughal, Ritika Ramani, Yi-Fei Huang, Adam Siepel   +4 more
openalex   +1 more source

Matrix extreme points and free extreme points of free spectrahedra

Optimization Methods and Software
66 ...
Epperly, Aidan, Evert, Eric, Helton, J. William, Klep, Igor   +3 more
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Study on utility optimization for randomized response mechanism

Tongxin xuebao, 2019
For the study of privacy-utility trade-off in local differential privacy,the utility optimization models of binary generalized random response mechanism for the case of differential privacy and approximate differential privacy were established.By graphic
Yihui ZHOU, Laifeng LU, Zhenqiang WU
doaj  

Interplay between disorder and inversion symmetry: Extreme enhancement of the mobility near the Weyl point in BiTeI

, 2015
We show experimental and theoretical evidence that BiTeI hosts a novel disordered metallic state named diffusive helical Fermi liquid (DHFL), characterized by a pair of concentric spin-chiral Fermi surfaces with negligible inter-valley scattering.
Kim, Heon-Jung, Kim, Ki-Seok, Kim, Kyoung-Min, Kitaura, M., Kulbachinskii, V. A., Ohnishi, A., Sasaki, M., Tomita, N.   +7 more
core   +1 more source