Results 71 to 80 of about 3,035,359 (290)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Extreme Points and Rotundity in Musielak-Orlicz-Bochner Function Spaces Endowed with Orlicz Norm

open access: yesAbstract and Applied Analysis, 2010
The criteria for extreme point and rotundity of Musielak-Orlicz-Bochner function spaces equipped with Orlicz norm are given. Although criteria for extreme point of Musielak-Orlicz function spaces equipped with the Orlicz norm were known, we can easily ...
Shaoqiang Shang, Yunan Cui, Yongqiang Fu
doaj   +1 more source

Interplay between disorder and inversion symmetry: Extreme enhancement of the mobility near the Weyl point in BiTeI

open access: yes, 2015
We show experimental and theoretical evidence that BiTeI hosts a novel disordered metallic state named diffusive helical Fermi liquid (DHFL), characterized by a pair of concentric spin-chiral Fermi surfaces with negligible inter-valley scattering.
Kim, Heon-Jung   +7 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Ergodicity and extremality of AMS sources and channels

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2003
Asymptotically mean stationary (AMS) sources (probability measures) and channels are considered as an extension of stationary sources and channels. It is shown that each extreme point of the set of all AMS sources is ergodic, but not vice versa, and that
Yûichirô Kakihara
doaj   +1 more source

Increase in extreme precipitation events under anthropogenic warming in India

open access: yesWeather and Climate Extremes, 2018
India has witnessed some of the most devastating extreme precipitation events, which have affected urban transportation, agriculture, and infrastructure.
Sourav Mukherjee   +3 more
doaj   +1 more source

Intercompartmental communication in senescence

open access: yesFEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz   +3 more
wiley   +1 more source

Preserving Spatial Patterns in Point Data: A Generalization Approach Using Agent-Based Modeling

open access: yesISPRS International Journal of Geo-Information
Visualization and interpretation of user-generated spatial content such as Volunteered Geographic Information (VGI) is challenging because it combines enormous data volume and heterogeneity with a spatial bias.
Martin Knura, Jochen Schiewe
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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