Results 71 to 80 of about 582,200 (259)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Non-extreme-Points Approach to Extreme Points of Integral Families of Analytic Functions
New Zealand Journal of Mathematics, 2021 Non extreme points of compact, convex integral families of analytic functions are investigated. Knowledge about extreme points provides a valuable tool in the optimization of linear extremal problems. The functions studied are determined by a 2-parameter collection of kernel functions integrated against measures on the torus.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
AtmosphereThe population of the southeastern USA is exposed to frequent extreme summertime high heat and humidity and is thus vulnerable to the resulting human thermal stress.
Alexandra Strelkow +3 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Extreme Point Sort Transformation Combined With a Long Short-Term Memory Network Algorithm for the Raman-Based Identification of Therapeutic Monoclonal Antibodies. [PDF]
Front Chem, 2022 Ling J +6 more
europepmc +1 more source
Extreme Points and Strongly Extreme Points in Orlicz Spaces Equipped with the Orlicz Norm
Zeitschrift für Analysis und ihre Anwendungen, 2003 Criteria for extreme points and strongly extreme points of the unit ball in Orlicz spaces with the Orlicz norm are given. These results are applied to a characterization of extreme points of B(L^1 + L^\infty) which corresponds to the result obtained by R. Grząślewicz and H.
Cui, Y., Hudzik, H., Płuciennik, R.
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source