Results 71 to 80 of about 3,017,157 (340)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Extreme Points and Rotundity in Musielak-Orlicz-Bochner Function Spaces Endowed with Orlicz Norm

Abstract and Applied Analysis, 2010
The criteria for extreme point and rotundity of Musielak-Orlicz-Bochner function spaces equipped with Orlicz norm are given. Although criteria for extreme point of Musielak-Orlicz function spaces equipped with the Orlicz norm were known, we can easily ...
Shaoqiang Shang, Yunan Cui, Yongqiang Fu
doaj   +1 more source

Application of the matrix exponential kernel [PDF]

, 1972
A point matrix kernel for radiation transport, developed by the transmission matrix method, has been used to develop buildup factors and energy spectra through slab layers of different materials for a point isotropic source.
Rohach, A. F.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Ergodicity and extremality of AMS sources and channels

International Journal of Mathematics and Mathematical Sciences, 2003
Asymptotically mean stationary (AMS) sources (probability measures) and channels are considered as an extension of stationary sources and channels. It is shown that each extreme point of the set of all AMS sources is ergodic, but not vice versa, and that
Yûichirô Kakihara
doaj   +1 more source

Increase in extreme precipitation events under anthropogenic warming in India

Weather and Climate Extremes, 2018
India has witnessed some of the most devastating extreme precipitation events, which have affected urban transportation, agriculture, and infrastructure.
Sourav Mukherjee, Saran Aadhar, Daithi Stone, Vimal Mishra   +3 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Preserving Spatial Patterns in Point Data: A Generalization Approach Using Agent-Based Modeling

ISPRS International Journal of Geo-Information
Visualization and interpretation of user-generated spatial content such as Volunteered Geographic Information (VGI) is challenging because it combines enormous data volume and heterogeneity with a spatial bias.
Martin Knura, Jochen Schiewe
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source