Results 41 to 50 of about 822,899 (303)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser +5 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Going on-line on a shoestring: An experiment in concurrent development of requirements and architecture [PDF]
, 2003 A number of on-line applications were built for a small university using a micro-sized development team. Four ideas were tested during the project: the Twin Peaks development model, using fully functional prototypes in the requirements elicitation ...
Haley, Charles, Nuseibeh, Bashar
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
RISK ASSESSMENT IN PROJECT PLANNING USING FMEA AND CRITICAL PATH METHOD [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014 This paper is based upon the research undertaken for the development of the doctoral thesis “Management of software projects based on object-oriented technology”.
Sandra Milena CHOLES ARVILLA
doaj
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
JISA (Jurnal Informatika dan Sains)The current condition of working desks often faces challenges such as poor management and inefficiency in space utilization, which complicates the adoption of Smart-Working culture at Xtra Cowork.
Daeng Ahmad Nurdin +3 more
doaj +1 more source
Extreme programming and its positive affect on software engineering teams [PDF]
, 2009 This paper presents an early empirical study on Extreme Programming (XP) practices employing Positive Affect metric.The study was conducted on university students doing development projects to gain an insight understanding of the effect of using agile ...
Omar, Mazni +1 more
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