Results 51 to 60 of about 4,777,273 (261)

Design Automation Using Exclusion-Based Hierarchical Computation for Power Electronics Converters in Harsh Environments

open access: yesIEEE Open Journal of Power Electronics
Designing power electronics converters for harsh environments is challenging due to the absence of components' performance under harsh conditions, the frequent transition and data-passing among various software, and the time-consuming and ...
Yudi Xiao   +8 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Seasonal Variability of Trends in Regional Hot and Warm Temperature Extremes in Europe

open access: yesAtmosphere, 2021
Extremely hot or warm weather over the course of the year may have significant impacts on many aspects of human life, the economy, and the natural environment.
Agnieszka Sulikowska, Agnieszka Wypych
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

The Spatiotemporal Evolution and Scenario Prediction of Agricultural Total Factor Productivity Under Extreme Temperature: Evidence from Jiangsu Province

open access: yesAgriculture
With the intensification of global climate change, frequent extreme temperature events pose increasing challenges to agricultural production. The aim of this study is to characterize the spatiotemporal evolution of county-level agricultural total factor ...
Yue Zhang, Yan Chen, Zhaozhong Feng
doaj   +1 more source

Geoengineering: Impact of Marine Cloud Brightening Control on the Extreme Temperature Change over East Asia

open access: yesAtmosphere, 2020
We investigated the effect of artificial marine cloud brightening on extreme temperatures over East Asia. We used simulation data from five global climate models which have conducted the GeoMIP G4cdnc experiment.
Do-Hyun Kim, Ho-Jeong Shin, Il-Ung Chung
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons   +33 more
wiley   +1 more source

A spatial vulnerability analysis of urban populations during extreme heat events in Australian capital cities [PDF]

open access: yes, 2013
Extreme heat events pose a risk to the health of all individuals, especially the elderly and the chronically ill, and are associated with an increased demand for healthcare services. In order to address this problem, policy makers need information about

core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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